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Articles by I Holme
Total Records ( 2 ) for I Holme
  S Abedini , I Holme , W Marz , G Weihrauch , B Fellstrom , A Jardine , E Cole , B Maes , H. H Neumayer , C Gronhagen Riska , P Ambuhl , H Holdaas and on behalf of the ALERT study group

Background and objectives: Renal transplant recipients experience premature cardiovascular disease and death. The association of inflammation, all-cause mortality, and cardiovascular events in renal transplant recipients has not been examined in a large prospective controlled trial.

Design, setting, participants, & measurements: ALERT was a randomized, double-blind, placebo-controlled study of the effect of fluvastatin on cardiovascular and renal outcomes in 2102 renal transplant recipients. Patients initially randomized to fluvastatin or placebo in the 5- to 6-yr trial were offered open-label fluvastatin in a 2-yr extension to the original study. The association between inflammation markers, high-sensitivity C-reactive protein (hsCRP), and IL-6 on cardiovascular events and all-cause mortality was investigated.

Results: The baseline IL-6 value was 2.9 ± 1.9 pg/ml (n = 1751) and that of hsCRP was 3.8 ± 6.7 mg/L (n = 1910). After adjustment for baseline values for established risk factors, the hazard ratios for a major cardiac event and all-cause mortality for IL-6 were 1.08 [95% confidence interval (CI), 1.01 to 1.15, P = 0.018] and 1.11 (95% CI, 1.05 to 1.18, P < 0.001), respectively. The adjusted hazard ratio for hsCRP for a cardiovascular event was 1.10 (95% CI, 1.01 to 1.20, P = 0.027) and for all-cause mortality was 1.15 (95% CI, 1.06 to 1.1.25, P = 0.049).

Conclusions: The inflammation markers IL-6 and hsCRP are independently associated with major cardiovascular events and all-cause mortality in renal transplant recipients.

  A. H Engebretsen , G Myklebust , I Holme , L Engebretsen and R. Bahr

Background: This study was conducted to determine if risk factors for groin injuries among male soccer players could be identified.

Hypothesis: Previous groin injuries, reduced function scores, age, findings on clinical examination, and low isometric groin strength are associated with increased risk of new groin injuries.

Study Design: Cohort study; Level of evidence, 3.

Methods: A total of 508 players representing 31 amateur teams were tested during the 2004 preseason for potential risk factors for groin injury through a questionnaire on previous injury and function score (Groin Outcome Score [GrOS]) and a clinical examination of the groin. Generalized estimating equations were used in univariate analyses to identify candidate risk factors, and factors with a P value <.10 were then examined in a multivariate model.

Results: During the soccer season, 61 groin injuries affecting 55 legs (51 players) were registered. The total incidence of groin injuries was 0.6 injuries per 1000 playing hours (95% confidence interval [CI], 0.4-0.7), 0.3 injuries per 1000 training hours (95% CI, 0.2-0.4), and 1.8 injuries per 1000 match hours (95% CI, 1.2-2.5). In a multivariate analysis, previous acute groin injury (adjusted odds ratio [OR], 2.60; 95% CI, 1.10-6.11) and weak adductor muscles as determined clinically (adjusted OR, 4.28; 95% CI, 1.31-14.0) were significantly associated with increased risk of groin injuries. A multivariate analysis based only on acute time-loss injuries revealed the 40-m sprint test result (adjusted OR, 2.03 for 1 standard deviation change [injured group faster]; 95% CI, 1.06-3.88; P = .03) and functional testing of the rectal abdominal muscles (adjusted OR, 15.5 [painful in 19% of the players in the injured group compared to 16% in the uninjured group]; 95% CI, 1.11-217; P = .04) as significant risk factors.

Conclusion: A history of acute groin injury and weak adductor muscles are significant risk factors for new groin injuries.

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