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Articles by Hossein Khedmat
Total Records ( 3 ) for Hossein Khedmat
  Hossein Khedmat , Farahnaz Fallahian , Hassan Abolghasemi , Seyed-Moayed Alavian , Bashir Hajibeigi , Seyyed Mohammad Miri and Amir Masoud Jafari
  To determine the frequency of hepatitis B, hepatitis C, Human Immunodeficiency Virus (HIV) and syphilis infections in Iranian blood donors. The prevalence of serological markers of hepatitis B, hepatitis C, HIV and syphilis infections were evaluated in 318029 consecutive volunteer blood donors attending to Tehran blood transfusion service from March 2005 to March 2006. Those positive for hepatitis B surface antigen, anti-HCV, anti-HIV1/2 and VDRL (venereal disease research laboratory) reactivity were analyzed with a second independent HBsAg enzyme immunoassay (EIA) and neutralization assay; an additional independent anti-HCV EIA and HCV-RIBA assay; second independent anti-HIV1/2 test, HIV western blot and fluorescent Treponemal Antibody Absorbed (FTA-ABS), respectively. In 318029 participants, prevalence of positive HBsAg, HCV RNA, HIV western blot and FTA-ABS was 1684 (0.487%), 323 (0.093%), 11 (0.003%) and 19 (0.005%), respectively. In 1014 subjects randomly selected from these 318029 participants, besides standard interview, physical exam and routine serologic tests; anthropometric and biochemical were studies. In this selected group frequency of HBsAg was 3 (0.29, 95% CI: 0-0.64%); frequency of anti-HCV was 21 (2.07%), but it was (0.09%, 95% CI: 0-0.30%) by confirmatory HCV RNA test; frequency of HIV-Ab1, 2 was 8 (0.78%), but it was 2 (0.19%, 95% CI: 0-0.48%) by confirmatory test; frequency of RPR was 0 (0%, 95% CI: 0-0.30%). Despite excluding subjects with high-risk behaviors by standard interview and physical examination, still a few asymptomatic hepatitis B, hepatitis C, HIV-infected subjects existed among volunteer blood donors with demographic and biochemical findings similar to non-infected ones.
  Hossein Khedmat , Shahram Agah and Saeed Taheri
  Hepatitis C virus infection, besides its substantial unfavorable impact on liver health, has several other manifestations, from which we have focused on its associations with insulin resistance and diabetes mellitus in an in vitro setting in this review of the literature. Several epidemiologic studies have already proven the strong association between chronic HCV infection and development of diabetes mellitus. However, attempts to clarifying molecular mechanisms for this association have not made up until recent years. We made a comprehensive review of the literature but we only found 6 studies investigating HCV impact on insulin signaling pathway in an in vitro era. We tried to review and compare the findings of these studies to show what we already know on the issue and what we still need to know.
  Hossein Khedmat , Mohsen Amini , Amir Masoud Jafari , Farhad Nasiri Afshar , Mohamad Javad Soltanpoor , Farahnaz Fallahian , Morteza Izadi and Mahboobeh Sadat Hosseini
  A cross-sectional study was carried out at the endoscopy unit of Bagqiyatollah University of Tehran. From February 2004 to June 2006, 305 consecutive dyspeptic patients were evaluated. With regard to standard methods, biopsies were taken and cultured. For each isolates Minimum Inhibitory Concentrations (MIC) for Metronidazole (MTZ), Amoxicillin (AMX), Tetracycline (TC) and Ciprofloxacin (CIP) were determined by Epsilometer test. Considering standard resistance breakpoints, our data was analyzed and resistance rates were reported. One hundred forty nine patients, had a positive culture. The resistance rate in H.P. isolates were as follows: MTZ (60.4%), CIP (40.3%), AMX (15.4%) and TC (10.7%). 82.6% of isolates were resistance to at least one drug. In resistance group: 56, 39 and 5% of isolates displayed single, dual and triple drug resistant pattern, respectively. In the different age groups or sex groups there was no difference (p>0.1) in the antibiotics resistance rates except for TC (p = 0.01) which was more common in older groups (17.1% versus 4.1%). In present study we confronted with markedly high rate of resistance to metronidazole and ciprofloxacin, furthermore other antibiotics displayed significant resistance rate and there was some level of overlap between resistances to these drugs. It seems that in Iran HP eradication is more difficult and demand more concern.
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