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Articles by Hossam Fouad Attia
Total Records ( 2 ) for Hossam Fouad Attia
  Mohamed Mohamed Soliman , Hossam Fouad Attia , Samir Ahmed El-Shazly and Osama Mesilhy Saleh
  Cinnamon Extracts (CE) are widely used in Middle East and Asian countries as herbal medication for diabetes. It contains biologically active substances which have in vivo hypoglycemic activity and probably improve insulin sensitivity. Up till now the molecular mechanism of CE on genes expression is not yet determined. In this study, we examined the effect of CE (200 mg kg-1 body weight) in obesity and diabetic Wistar rats by testing its effect on genes related to lipids and glucose metabolism. Firstly, to test anti-obesity actions of CE, rats were fed High Fat Diet (HFD) for 3 months then treated with CE for 2 months. Secondly, experimentally diabetic rats were treated with CE for 2 months to examine its antidiabetic action. The results showed that CE treatment did not show any significant changes in plasma levels of obesity related parameters including lipid profiles, leptin and lipase enzyme. However, liver histology showed decrease in lipid and glycogen accumulation in CE treated rats. Moreover, CE induced significant (p<0.05) decrease in haptoglobin levels. In diabetic experiments, CE treatment normalized significantly (p<0.05) the increase in lipid profiles and glucose levels occurred in diabetic rats. In parallel, CE lowered glucose levels through the increase in insulin secretion from still working β cells. The antidiabetic action of CE was confirmed as CE treated diabetic rats showed an increase in mRNA expression of leptin, PPAR-gamma and adiponectin. In conclusion, CE is not anti-obesity herb but has antidiabetic and insulin-mimetic actions through the regulation of genes related to lipid and glucose metabolism.
  Ismail Tamer Ahmed , Mohamed Mohamed Soliman , Hossam Fouad Attia , Munoz Cuellar Lino , Xu Bo , Ying Zhang and Tadashi Yamamoto
  Eicosapentaenoic Acid (EPA) is an omega-3 fatty acid (polyunsaturated fatty acid) that has pleiotropic effects as hypolipidemic and anti-inflammatory actions. Podocytes injury in the renal glomeruli has been proposed as the crucial mechanism in the development of focal segmental glomerulosclerosis or nephrosis. The effect of EPA on Puromycin aminonucleoside (PAN) induced nephrosis was tested. EPA was administered daily for 28 days at a dose of 1 g kg-1 b.wt. then PAN was injected intravenously at a dose of 6 mg/100 g of body weight followed by EPA for 6 days. PAN nephrosis induced increase in proteinuria, lipid profiles, podocytes proteins expression and immunolocalization. EPA induced decrease in proteinuria and lipid profiles induced by PAN nephrosis. Also, EPA induced significant down-regulation in expression of connexin 43 and synaptopodin. Moreover, EPA induced 50% decrease in glomerular cell adhesion induced by PAN nephrosis. Immunoflerusecnce shows expression of desmin and connexin 43 in rat glomeruli that increased by PAN and decreased by EPA. These findings collectively showed that EPA has reno-protective effect during inflammation.
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