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Articles by Hossain Uddin Shekhar
Total Records ( 2 ) for Hossain Uddin Shekhar
  Hossain Uddin Shekhar , Yearul Kabir , Mosharaf Hossain , Mesbah Uddin , Kaniz-Khatun- E-Jannat , Shahdat Hossain and Hussain Shahjalal
  To assess the prevalence of transfusion-mediated viral infections in multi-transfused thalassemics in Bangladesh, forty-two thalassemic children (Male = 24, Female = 18) were recruited. All children were less than twelve years of age. Seromarkers for hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) were studied in these children prior to initiate blood transfusion and after they had received an average of 17.0±1.0 blood transfusions over a ten-month study period. The HBV and HCV markers were significantly higher in post-transfused subjects as compared to their pre-transfusion levels (HBsAg: 19.0 vs. 7.1%, p = 0.021 and anti-HCV: 16.7 vs. 2.4%, p<0.001). None of the thalassemic children was positive for HIV before or after transfusion. The serum total bilirubin, alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase levels also were significantly higher (p = 0.001, <0.001, <0.001 and <0.001, respectively) in post-transfused patients. Thus, HBV and HCV infections are major problems in multi-transfused thalassemic children in Bangladesh.
  Hossain Uddin Shekhar , Hussain Md. Shahjalal , Rumana Ahmed , Mesbah Uddin and Kaniz-Khatun-E-Jannath
  Diabetic patients are vulnerable to different lethal diseases including cardiovascular disease, which is still ranked as the number one killer disease in the world. In the present study, the vulnerability of diabetic patients to cardiovascular disease was evaluated considering apoB level as a predictor. Randomly selected Bangladeshi 96 type 2 diabetic patients (M = 48, F = 48) and 49 healthy non-diabetic individuals (M = 37, F = 12) were recruited to compare their anthropometric and biochemical features. Among the diabetic subjects 32 were hypercholesterolemic (LDL-C>150 mg dL-1) and 64 were normocholesterolemic (LDL-C<150 mg dL-1). The biochemical parameters compared were total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C) and apolipoprotein B (apoB). The values for the diabetic patients vs. control were: TC, 214±46 vs. 186±18 mg dL-1; LDL-C, 143±40 vs. 120±18 mg dL-1; TG, 192±79 vs.141±33 mg dL-1 and HDL-C, 35±6 vs. 39±7 mg dL-1; with all p value<0.05. The values for the normocholesterolemic diabetic patients vs. control were: TC, 189±28 vs.186±18 mg dL-1; LDL-C, 120±23 vs. 120±18 mg dL-1; TG, 184±84 vs. 141±33 mg dL-1 and HDL-C, 35±7 vs. 39±7 mg dL-1; of which values of TG and HDL-C were significant. Serum apoB level for the diabetic patients vs. control was 1.15±0.28 vs. 0.926±0.25 g L-1 (p<0.05) and the normocholesterolemic diabetic patients vs. control was 1.06±0.26 vs. 0.926±0.25 g L-1 (p<0.05). 47% (n = 30) of the normocholesterolemic diabetic patients had hyper-apoB, of which 22% were hypertriglyceridemic and 25% were normotriglyceridemic. Surprisingly, hyper-apoB was also found in 14% of control. Thus apoB identified the high-risk phenotypes in normocholesterolemic diabetic patients and it should be used to evaluate the lipidic pattern of these patients.
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