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Articles by Hongling Wang
Total Records ( 2 ) for Hongling Wang
  Lihua Tang , Hongling Wang , Yun Luo , Lijun Huang , Hongxia Gong , Hui Zhang and Jianyue Wang
  V. parahaemolyticus is one of the most important foodborne pathogens in China and other countries. In this study, researchers investigated the contamination of V. parahaemolyticus in shellfish during different seasons in Zhoushan islands. Meanwhile, researchers reported the prevalence, molecular characterization and virulence genes of V. parahaemolyticus from shellfish and clinical patients. In shellfish, the positive rate was 85, 80, 75 and 10%, respectively in different seasons from Spring to Winter. Among the shellfish isolates, there was no tdh+ strains and only 4% trh+ strains. The prevalence of V. parahaemolyticus in clinical samples was 36 and 77.78% of clinical strains were tdh+, toxRS/new+, orf8+ and 5.56% clinical strains were trh+. In 80% similarity, the total of 53 strains could be divided into twenty nine types. Most of the shellfish strains present various patterns with far relationship while all the pandemic strains from clinical samples belonged to same clone group with 82.8% similarity. The tdh+, toxRS/new+ and orf8+ strains were the main epidemic strains in Zhoushan islands.
  Suzan McNamara , Hongling Wang , Nessrine Hanna and Wilson H. Miller Jr.
  Interactions between retinoic acid (RA) receptor α (RARα) and coregulators play a key role in coordinating gene transcription and myeloid differentiation. In patients with acute promyelocytic leukemia (APL), the RARα gene is fused with the promyelocytic leukemia (PML) gene via the t(15;17) translocation, resulting in the expression of a PML/RARα fusion protein. Here, we report that topoisomerase II beta (TopoIIβ) associates with and negatively modulates RARα transcriptional activity and that increased levels of and association with TopoIIβ cause resistance to RA in APL cell lines. Knockdown of TopoIIβ was able to overcome resistance by permitting RA-induced differentiation and increased RA gene expression. Overexpression of TopoIIβ in clones from an RA-sensitive cell line conferred resistance by a reduction in RA-induced expression of target genes and differentiation. Chromatin immunoprecipitation assays indicated that TopoIIβ is bound to an RA response element and that inhibition of TopoIIβ causes hyperacetylation of histone 3 at lysine 9 and activation of transcription. Our results identify a novel mechanism of resistance in APL and provide further insight to the role of TopoIIβ in gene regulation and differentiation.
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