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| Articles
by
Hong-Sik Kong |
Total Records (
1 ) for
Hong-Sik Kong |
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O. Baatartsogt
,
K. Choi
,
P.K. Mandal
,
Hee-kyong Lim
,
Guan-Hao Li
,
Hong-Sik Kong
,
Dae-Hyun Hahm
,
Chi-Ho Lee
and
Jun-Heon Lee
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To get insights into pathological pathways of Post Traumatic
Arthritis (PTA) this study was done on gene expression profile of synovial
cells of knee using gene chip analysis developing experimental post traumatic
arthritis (ETA) in swine. ETA was induced by transection of the Anterior
Cruciate Ligament (ACL) of left knee in 3 piglets. Articular cartilage
and synovial tissues were obtained after 0, 2, 5 and 8 weeks for histopathologic
examination. Synovial cells collected after sacrificing the piglet at
8 weeks, were used at 5 passage for gene expression profiling using Affimetrix
Gene Chip. Histopathologic examination showed overt chronic inflammation
indicating the development of ETA. Through genome analyses it was observed
that 87 known genes were up-regulated and 76 known genes were down regulated.
By analyzing, it was found that many genes with differential expression
are related to inflammation, immune response, lipid binding, cell adhesion,
growth activity and muscle development. The present study provided an
insight into the TA related gene expression pattern. The genome analysis
of synovial cells provided us new candidate molecules which may be useful
to understand the pathogenesis of Post Traumatic Arthritis (PTA). The
established porcine model may serve as in vivo disease model for
further research on traumatic arthritis to elucidate molecular pathogenesis. |
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