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Articles by Hong Li
Total Records ( 7 ) for Hong Li
  Hong Li and Hongxing Yang
  This paper reports the investigation results on application of the solar assisted air source heat pump systems for hot water production in Hong Kong. A mathematical model of the system is developed to predict its operating performance under specified weather conditions. The optimum flow rate from the load water tank to the condenser is proposed considering both the appropriate outlet water temperature and system performance. The effect of various parameters, including circulation flow rate, solar collector area, tilt angle of solar collector array and initial water temperature in the preheating solar tank is investigated, and the results show that the system performance is governed strongly by the change of circulation flow rate, solar collector area and initial water temperature in the preheating solar tank.
  Hong Li , Jian-guo Wu , Hong-wei Zhang , Wei Wang , Yuan-xing Zhang and Jian-ning Zhang
  Background and Objective: Glioma is the most commonly detected primary brain tumor found in adults and has very high rate of morbidity and mortality. The present study was performed to investigate the effect of gedunin on viability, migration and invasion of human glioblastoma multiforme, U-251 MG cell line. Materials and Methods: Invasion assay was performed using 24-well cell culture invasion chamber (Corning Inc., Tewksbury, MA, USA) coated with 8.0 μm Matrigel™ (Becton Dickinson, Bedford, MA, USA). For real-time polymerase chain reaction U-251 MG cells were distributed on to the six-well tissue culture plates and treated with gedunin for 24 h. Qiagen RNeasy Mini Kit was used for the isolation of total RNA from the cells. Results: The results revealed that exposure of U-251 MG cells to gedunin reduced the viability of U-251 MG cells to 28% compared to 98% in control group. Analysis of cell migration and invasion showed a significant inhibition by gedunin at a concentration of 20 μM after 24 h. Gedunin treatment suppressed the expression of focal adhesion kinase (FAK), metalloproteinases (MMP)-7, MMP-9 and uPA which play a vital role in inducing migration of carcinoma cells. The inhibition was significant (p<0.005) at all the tested concentrations except 5 μM after 24 h in U-251 MG cells. In addition the real-time PCR analysis revealed a marked reduction in the expression of MMP-9, FAK and Rho kinases-ROCK-1 (ROCK-1) mRNA by gedunin treatment. Conclusion: Thus, gedunin treatment caused inhibition of proliferation, migration and invasion in U-251 MG cells through inhibition of MMP-9, FAK and ROCK-1. Therefore, gedunin is a potent agent for the treatment of tumor growth.
  Hong Li , Chao Hou , Jing-Min Shi and Shi-Guo Zhang
  A new one-dimensional copper(II) coordination polymer, [Cu(ยต-HL)(H2O)2(NO3)]n (HL = monodeprotonated 2,2`-bypyridine-3,3`-diol), was synthesized and its crystal structure determined by X-ray crystallography. In the crystal Cu(II) is located a distorted octahedral coordination geometry and each HL coordinates two Cu(II) ions with its two N atoms and an O atom of deprotonated hydroxyl, giving a one-dimensional chain. The variable-temperature (2-300 K) magnetic measurements, analyzed using a one-dimensional Cu(II) magnetic interaction formula, indicate the existence of very weak ferromagnetic coupling with 2J = 0.014 cm-1.
  Hong Li , Ting-Ting Sun , Shi-Guo Zhang and Jing-Min Shi
  A new binuclear copper(II) complex, [Cu21,1-N3)2(PP)2)] ⋅ 2ClO4 (PP = 2,6-dipyrazol-1-yl-pyridine), was synthesized with double azide as asymmetric end-on bridge ligand and 2,6-dipyrazol-1-yl-pyridine as the terminal ligand. The crystal structure was determined by X-ray crystallography. Cu(II) is located in a distorted square pyramidal geometry, and azide bridges the equatorial-axial linking two Cu(II) atoms with a separation of 3.3595(11) Å. The fitting for the data of the variable-temperature (2-300 K) magnetic susceptibilities by using the Curie-Weiss law gives the Weiss temperature θ = -7.830 K, indicating a very weak anti-ferromagnetic interaction between the bridging Cu(II) complexes.
  Yan Wang , Hong Li , Qiyi Tang , Gerd G. Maul and Yan Yuan
  Herpesvirus lytic DNA replication requires both the cis-acting element, the origin, and trans-acting factors, including virally encoded origin-binding protein, DNA replication enzymes, and auxiliary factors. Two lytic DNA replication origins (ori-Lyt) of Kaposi's sarcoma-associated herpesvirus (KSHV) have been identified, and two virally encoded proteins, namely, RTA and K8, have been shown to bind to the origins. In this study, we sought to identify cellular factors that associate with ori-Lyt by using DNA affinity purification and mass spectrometry. This approach led to identification of several cellular proteins that bind to KSHV ori-Lyt. They include topoisomerases (Topo) I and II, MSH2/6, RecQL, poly(ADP-ribose) polymerase I (PARP-1), DNA-PK, Ku86/70 autoantigens, and scaffold attachment factor A (SAF-A). RecQL appears to associate with prereplication complexes and be recruited to ori-Lyt through RTA and K8. Topoisomerases, MSH2, PARP-1, DNA-PK, and Ku86 were not detected in prereplication complexes but were present in replication initiation complexes on ori-Lyt. All these cellular proteins accumulate in viral replication compartments in the nucleus, indicating that these proteins may have a role in viral replication. Topo I and II appear to be essential for viral DNA replication as inhibition of their activities with specific inhibitors (camptothecin and ellipticine) blocked ori-Lyt-dependent DNA replication. Furthermore, inhibition of PARP-1 with chemical inhibitors (3-aminobenzamide and niacinamide) resulted in decreased ori-Lyt-dependent DNA replication, whereas hydroxyurea, which raises PARP-1 activity, caused an increase in the DNA replication, suggesting a positive role for PARP-1 in KSHV lytic DNA replication.
  Deyu Guan , Nihal Altan-Bonnet , Andrew M. Parrott , Cindy J. Arrigo , Quan Li , Mohammed Khaleduzzaman , Hong Li , Chee-Gun Lee , Tsafi Pe`ery and Michael B. Mathews
  Nuclear factor 90 (NF90) and its C-terminally extended isoform, NF110, have been isolated as DNA- and RNA-binding proteins together with the less-studied protein NF45. These complexes have been implicated in gene regulation, but little is known about their cellular roles and whether they are redundant or functionally distinct. We show that heterodimeric core complexes, NF90-NF45 and NF110-NF45, exist within larger complexes that are more labile and contain multiple NF90/110 isoforms and additional proteins. Depletion of the NF45 subunit by RNA interference is accompanied by a dramatic decrease in the levels of NF90 and NF110. Reciprocally, depletion of NF90 but not of NF110 greatly reduces the level of NF45. Coregulation of NF90 and NF45 is a posttranscriptional phenomenon, resulting from protein destabilization in the absence of partners. Depletion of NF90-NF45 complexes retards cell growth by inhibition of DNA synthesis. Giant multinucleated cells containing nuclei attached by constrictions accumulate when either NF45 or NF90, but not NF110, is depleted. This study identified NF45 as an unstable regulatory subunit of NF90-NF45 complexes and uncovered their critical role in normal cell division. Furthermore, the study revealed that NF90 is functionally distinct from NF110 and is more important for cell growth.
  Sarah Hamilton Boyles , Hong Li , Tomi Mori , Patricia Osterweil and Jeanne-Marie Guise
 

OBJECTIVE: To estimate the effect of mode of delivery on the incidence of urinary incontinence in primiparous women.

METHODS: A population-based survey was mailed to all Oregon women who delivered a liveborn neonate in a 1-year period. Data were collected on urinary incontinence, childbirth experience, and other risk factors for incontinence at 3-6 months postpartum. Univariable analyses were conducted using t tests and Wilcoxon rank-sum tests for continuous variables and χ2 tests for categorical variables. Logistic regression analyses were used to estimate odds ratios and 95% confidence intervals for demographic and clinical risk factors.

RESULTS: A total of 15,787 women completed the survey, for a response rate of 39%. Of these women, 5,599 were primiparous, completed the survey in the desired timeframe, submitted information on their urinary continence, and did not have incontinence before pregnancy. A total of 955 (17.1%) reported leakage of urine. Women who had vaginal deliveries were more likely to have urinary incontinence than women who had cesarean deliveries (odds ratio 4.96 [95% confidence interval 3.82-6.44], P<.001). This risk increased with assisted delivery and perineal laceration. No statistical difference in the incidence of urinary incontinence was found among women who had elective cesarean deliveries (6.1%), women who had cesarean deliveries after laboring (5.7%), and women who had cesarean deliveries after laboring and pushing (6.4%).

CONCLUSION: Urinary incontinence is common in the immediate postpartum period after a woman's first pregnancy. Although vaginal delivery increases the risk of urinary incontinence, labor and pushing alone without vaginal delivery do not appear to increase this risk significantly.

 
 
 
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