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Articles by Hesham Abdel-Hady
Total Records ( 2 ) for Hesham Abdel-Hady
  Fatma A. Shaaban , Gehan A. Fathi , Ayman M. Hammad , Hesham Abdel-Hady and Rizk EL-Baz
  The aim of the present study was to assess plasma endothelin-1 (ET-1) and Nitric Oxide (NO) levels in children with Insulin-dependent Diabetes Mellitus (IDDM) and their relation to the degree of metabolic control and disease duration. The study group consisted of 34 children with IDDM and 17 healthy controls of matched age and sex, recruited from the Pediatric Endocrinology and Diabetes Unit; Mansoura University Children`s Hospital, Egypt, during the period January to March, 2005. Plasma ET-1 and NO levels were assessed by enzyme immunoassay and we evaluated their possible relation with metabolic control and disease duration. Plasma ET-1 levels were significantly higher in diabetic patients compared to controls, (p = 0.02). Patients with poor or moderate metabolic control had significantly higher levels of ET-1 compared to those with ideal control (p = 0.004 and 0.001), respectively. A +ve significant correlation was found between plasma ET-1 levels and NO, HbA1c levels and disease duration, (p = 0.004, 0.001 and 0.02), respectively. Although plasma NO levels in diabetic patients were not significantly different from controls, yet they were significantly higher in patients with poor metabolic control compared to those with ideal control (p<0.001). In children with IDDM, poor metabolic control and increased disease duration are associated with increased ET-1 production, which may be related to future diabetic complications. The elevated plasma NO levels in poorly controlled patients may suggest a compensatory protective response towards increased ET-1 production.
  Shadia El-Sallab , Hesham Abdel-Hady , Ekbal Abu-Hashim and Mohamed Matter
  Nitric oxide (NO) and carbon monoxide (CO) are proposed to regulate physiologic vascular tone, blood pressure, and tissue perfusion. To investigate their role in the pathogenesis of neonatal sepsis, plasma levels of NO and CO in 45 neonates with clinical evidence of sepsis plus positive blood culture as well as in 20 healthy neonates were assessed. Significantly higher plasma levels of NO and CO in sepsis group compared with control group were found (56.4 ± 21.1 vs. 33.4 ± 12.1 Fmol L-1, p < 0.0001; 44.0 ± 12.0 vs 23.7 ± 8.5 nmol L-1, p < 0.0001, respectively). This increase in NO and CO levels occurred independent of gestational age, onset of sepsis, and gram stain of the isolated organism. Moreover, there were significantly higher plasma levels of NO and CO in septic infants who required inotropic support compared with those who did not require this support (p<0.0001). Plasma CO was higher in non-survivors compared with survivors (p=0.003). Significantly positive correlation between plasma NO and CO was observed. In conclusion, plasma NO and CO was increased in neonatal sepsis. This increase is independent of gestational age, onset of sepsis and gram stain of the isolated organism. Assay of plasma CO and NO may help to assess the severity of sepsis and progression to septic shock. The role of nitric oxide synthase (NOS) and heme oxygenase (HO) inhibitors in the management of neonatal sepsis should be investigated in further trials.
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