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Articles by Heidarali Esmaeili
Total Records ( 2 ) for Heidarali Esmaeili
  Heidarali Esmaeili , Monireh Halimi and Amir Hagigi
  According to an old notion, the axis of “brain-gut-skin” plays a significant role in the pathogenesis of acne vulgaris. This study aimed to compare gastrointestinal dysfunction symptoms in patients with different severities of acne vulgaris with their normal counterparts. In this cross-sectional, case-control study, 120 adolescents and young adults were recruited from two teaching dermatological clinics over a one-year period (2012-2013). These participants were 30 normal subjects (controls), 30 patients with mild acne vulgaris, 30 patients with moderate acne vulgaris and 30 patients with severe acne vulgaris. Frequency of gastrointestinal dysfunction symptoms including halitosis, gastric reflux, abdominal bloating, abdominal discomfort, constipation and diarrhea was compared between the controls and the patients. Serum lipids profile was also compared between the patients and the controls. All the four studied groups were matched for their members’ age and sex. Controls and the cases with mild acne vulgaris were comparable in terms of the frequency of gastrointestinal symptoms. Frequencies of abdominal bloating (30% vs. 10%, p = 0.05) and constipation (36.7% vs. 13.3%, p = 0.04) were significantly higher in the group with moderate acne comparing with the controls. They were also significant more frequent in the patients with severe acne comparing with the controls (40%, p = 0.01 and 46.7%, p = 0.01, respectively). Comparing with the controls, serum lipids profile was significantly deranged only in the cases with severe acne vulgaris. This study showed that gastrointestinal dysfunction is associated with moderate-to-sever acne vulgaris. In addition, serum lipids profile may be abnormal only in severe acne vulgaris.
  Heidarali Esmaeili and Kazem Ghahremanzadeh
  Recently, it is hypothesized that there might be an association between immunological disorders and cervical premalignant and malignant abnormalities. Related studies have been generally focused on some particular autoimmune disease, specially the Systemic Lupus Erythematosus (SLE). This study aimed at comparing the rate of Pap smear abnormalities in female patients with autoimmune diseases and normal counterparts. In a case-control setting, 118 female patients with various autoimmune diseases (the case group) and 118 healthy female counterparts (the control group) were recruited in Tabriz Imam Reza Teaching Centre in a 24 months period of time. The two groups were matched for demographics and known risk factors of cervical malignancy. Frequencies of abnormal Pap smear testing were compared between the two groups. The autoimmune disorders were SLE (74 patients), rheumatoid arthritis or RA (32 patients), systemic sclerosis or SS (7 patients) and ankylosing spondylitis or AS (5 patients) in the case group. Frequency of abnormal Pap smear testing was significantly higher in the case group comparing with that in the controls (7.6% vs. 1.7%; p = 0.03). Frequency of abnormal Pap smear testing was higher in the patients with SLE (8.1%) and RA (9.3%) comparing with that in the controls; However, these differences were marginally nonsignificant (p = 0.06 and p = 0.07, respectively). Frequency of cases with abnormal Pap smear testing was not statistically different between the autoimmune disorders (p = 0.99). Based on these findings and in conclusion, there might be an association between the autoimmune disorders and occurrence of premalignant or malignant lesions in cervix. Further studies with larger samples sizes are recommended.
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