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Articles by Heba Sayed Assal
Total Records ( 2 ) for Heba Sayed Assal
  Heba Sayed Assal , Hanaa M. Emam and Nagwa Abd EL-Ghaffar
  The present research was carried out to evaluate the physical (PCS) and mental (MCS) component summary scales in hemodialysis patients as compared to healthy subjects at a baseline and two years later. 130 patients on hemodialysis (mean age 40.6±8.1 years) were enrolled in the study between February 2003 to February 2005. The short-form with 36 (SF-36) questionnaire was given every 6 months to hemodialysis patients. Results were compared to the general population and changes in QoL over time were determined. Mean PCS was 34±15.46 and mean MCS was 38.80±15.17 compared to the general population there were significant decline in PCS and MCS at baseline and two years later. There was no significant correlation between causes of End-Stage Renal Disease (ESRD) and Quality of Life (QoL), except for diabetes mellitus as regard MCS. High levels of serum albumin and hemoglobin was associated with highly significant quality of life. Serum albumin was a good predictor for quality of life in this study. Adequacy of dialysis treatment in hemodialysis patients was determined by serum albumin, hematocrit, KT/V and Urea Reduction Ratio (URR). Present results showed the negative impact that ESRD and hemodialysis treatment have on self-assessed physical and mental health and it is important to treat all factors that induce hypoalbuminemia as well as anaemia.
  Heba Sayed Assal , Mohamed Fath-Allah and Ashraf Elsherbiny
  Adiponectin is an adipocyte-secreted protein that circulates in high concentrations in the serum and acts to increase insulin sensitivity. Leptin is an adipocyte-derived hormone that acts to reduce food intake and increase energy expenditure by binding and activating its specific receptor in the hypothalamus. Clinical aspects of diabetes and obesity are somewhat different, even at similar levels of insulin resistance. The purpose of this study was carried out to determine serum leptin, serum adeponectin and to compare leptin to adeponectin ratio in diabetic and non-diabetic obese participants. One hundred patients were enrolled in the study, 40 type 2 diabetic obese, 40 obese persons and 20 non-obese volunteers as a control group. Body mass index and waist-to-hip ratio was calculated. Laboratory investigations were: alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, Creatinine, fasting and post-prandial glucose levels, glycated haemoglobin (HbA1c), cholesterol, triglycerides (TGs), HDL-cholesterol, LDL-cholesterol, leptin and adiponectin. Subjects were categorized into 3 groups, Group I: included 40 obese (mean BMI was 33.6±2.0 kg m-2) patients with type II diabetes. The mean of HbA1c was 6.9±1.5%; serum TGs was 141.6±93 mg %; serum creatinine was 0.86±0.15 mg %; serum leptin was 12.9±0.35 ng mL-1; serum adiponectin was 6.44±0.16 μg mL-1. Group II: included a total number of 40 obese (mean BMI was 34.8±1.2 kg m-2) participants The mean of HbA1c was 5.6±2.7%; serum TGs was 115±54 mg %; serum creatinine was 0.95±0.2 mg %; serum leptin was 8.7±0.5 ng mL-1; serum adiponectin was 7.84±0.25 μg mL-1. Group III: included a total number of 20 non-obese volunteers (age ranged from 28 to 58 with a mean of 44.9±14.5 years; 13 males and 7 females). The mean of HbA1c was 5.2±0.5%; serum TGs was 104±22 mg %; serum creatinine was 0.84±0.5 mg %; serum leptin was 5.2±0.2 ng mL-1; serum adiponectin was 9.2±0.3 μg mL-1. Present results showed that obesity, WHR and DM are inversely associated with adiponectin, directly associated with leptin and leptin/adiponectin ratio.
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