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Articles by Hayati Yuksel
Total Records ( 2 ) for Hayati Yuksel
  A. Fatih Fidan , Ismail Kucukkurt , Hayati Yuksel , Ayse Ozdemir , Sinan Ince and Yilmaz Dundar
  The aim of this study, was to examine the effects of Yucca schidigera, Quillaja saponaria and mixture of both plants on tissue antioxidant defense systems, lipid peroxidation and histopathological changes on streptozotocin-induced diabetic rats. Animals were allocated into 5 groups of each containing 10 rats. Control (C) and Diabetic Control group (D) were fed by Standart Rat Feed (SRF). The other diabetic groups, Yucca schidigera group (DY), Quillaja saponaria group (DQ) and mix group (DQY) were fed ad libitum using SRF +100 ppm Yucca schidigera powder (Sarsaponin 30®), SRF +100 ppm Quillaja saponaria powder (Nutrafito®) and SRF+100 ppm Yucca schidigera-Quillaja saponaria powder (Nutrafito Plus®), respectively for 3 weeks. MDA levels in liver and kidney of the rats significantly increased in D group compared to control. MDA levels in DY, DQ and DQY groups significantly decreased in liver and kidney of the diabetic rats. On the other hand, the liver and kidney GSH concentrations significantly decreased in D, DY and DQY groups compared to control and DQ group. The SOD levels in liver significantly increased in DY, DQ and DQY groups compared to D group. The kidney SOD levels in D and DY group significantly decreased compared to control and other groups. On the other hand, treatment of diabetic rats with Quillaja saponaria and Quillaja saponaria-Yucca schidigera mixtures prevented the alteration in liver and kidney pathology with the return to their normal texture. Consequently, in buffering the negative impacts of increased oxidative stress in DM and in preventing or mitigating diabetic complications, it was seen that Quillaja saponaria was more effective than Yucca schidigera. Moreover, it can be considered that these plants could support the treatment of the disease by antioxidant effects.
  A. Fatih Fidan , I. Hakk Cigerci , Nalan Baysu-Sozbilir , Ismail Kucukkurt , Hayati Yuksel and Hikmet Keles
  In the present study, we have sought the effects of lindane on antioxidant parameters and nitric oxide (NOx) levels of blood, liver, kidney and brain, as well as its histopathological evaluation in rats. The rats were divided into four groups each containing 10 rats: control; L10, L20 and L40. C group was administered by 1 mL day 1 pure olive oil. The other groups, L10, L20 and L40 were administrered by 10, 20 and 40 mg/kg/bw orally lindane, respectively for 4 weeks. Administration of lindane caused an increase in malondialdehyde (MDA), total antioxidan activities (AOA) and NOx concentrations in blood (p<0.05), but 10 mg kg-1 dosage of lindane treatment did not cause any difference in blood and tissue MDA levels. Moreover, MDA levels in the liver, kidney and brain increased (p<0.05) at 20 and 40 mg kg-1 dosage of lindane treatment. The liver, kidney and brain reduced glutathione (GSH) concentrations decreased in all lindane groups (p<0.05). An increase in the kidney NOx concentrations was observed in lindane treated animals (p<0.05). However, liver NOx levels were increased only L40 group (p<0.05). Brain GSH concentrations between groups did not differ. Histopathologically, severe liver and kidney congestion were detected in lindan groups, but no specific changes was seen in the brain. While no significant histopathological changes were observed in the tissues of the animals in L10 group, megalocytosis in hepatocytes, periacinar settled parancimateus and vacuolar degeneration as well as sinusoidal and venous c ongetion and also periportal lymphocytic infiltrations were observed in liver of L20 and L40 groups. Medullar and cortical haemorrhagie, degeneration and vacuolisations of proximal convoluted tubules were seen in kidney. Furthermore, hyperemie was seen in the parancimateus brain vessels.
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