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Articles by Hatice PASAOGLU
Total Records ( 2 ) for Hatice PASAOGLU
  Nilufer BAYRAKTAR , Hatice PASAOGLU , Aydin PASAOGLU , Memduh KAYMAZ , Gursel BIBEROGLU and Sevsen KULAKSIZOGLU
 

Aim: It is assumed that reactive oxygen species and lipid peroxidation cause cell membrane damage and play a role in oncogenesis. Carnitine and acyl esters, which play a role in intracellular short-, medium-, and long-chain fatty acid metabolism, are one of the defense mechanisms against free radical toxicity. It is thought that the protective effects of carnitine are related with its role in lipid metabolism. In our study, we analyzed the relation between malondialdehyde (MDA) and free carnitine, and C2, C3, C4, C5, C6, C8, C10, C12, C14:1, C14, C16:1, C16, C18:1, C18, C20:4 carnitine levels in glial tumors [glioblastoma multiforme (GBM) (n = 29), high-grade astrocytoma (n = 8) and low-grade astrocytoma (n = 8)] to determine whether there is a relation between carnitine-acyl carnitines and lipid peroxidation in carcinogenesis.

Materials and Methods: The present study examined the free carnitine and C2, C3, C4, C5, C6, C8, C10, C12, C14:1, C14, C16:1, C16, C18:1, C18, C20:4 levels of glial tumors in tandem mass spectrometry. We measured MDA levels using HPLC system.

Results: There was a significant correlation between MDA and C20:4 carnitine levels in GBM. C20:4 carnitine levels increased with increasing MDA levels (p = 0.000, r = 0.916), but no significant correlation was found in the other groups.

Conclusions: In conclusion, measurement of only carnitine-MDA relation did not reflect any significant correlation. Detailed studies, including measurement of parameters showing antioxidant status and tumor cellular metabolism, are necessary.

  Hatice PASAOGLU , Fatma Ebru OFLUOGLU DEMIR , Canan YILMAZ DEMIRTAS , Ahmed HUSSEIN and Ozge Tugce PASAOGLU
  Aim: To investigate the effect of caffeine on the levels of malondialdehyde (MDA), nitric oxide (NO), and advanced oxidation protein products (AOPP) in the liver and heart tissues of rats. Materials and methods: The current study included 30 rats, which were divided into 3 groups: a control group and 2 caffeine-treated groups. Group 1 was given caffeine at 30 mg/kg and Group 2 was given caffeine at 100 mg/kg (a high nontoxic dose) for 14 days. Results: MDA and AOPP levels in the liver tissue of the caffeine-treated groups decreased significantly as a result of the dose. MDA and AOPP levels in the heart tissue also decreased, but this effect was not significantly affected by the dose. NO levels in the liver tissue of the caffeine-treated groups were higher than those in the control group; in the heart tissues, however, NO levels were not significantly affected by caffeine. Conclusion: These results show that the short-term consumption of 2 different doses of caffeine may potentially protect against oxidative stress in the liver. This effect is related to the dose of caffeine in the liver tissue. Further studies will be needed to discover the mechanisms responsible for these findings.
 
 
 
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