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Some of synthesized heterocyclic pyrimidine, pyrimidine, furopyridine derivatives and their nucleoside candidates (2-14) were previously prepared and were founded to have some aspects of structural similarity with many anti-inflammatory agents. Therefore, these agents were screened for this property. The evaluation of the anti-inflammatory activities was based on evaluation of the abilities of these compounds in protection against carrageenan-induced edema. The anti-inflammatory activities of the tested compounds further confirmed based on evaluation of the abilities of these compounds to inhibit plasma PGE2. These compounds showed potent anti-inflammatory activity with low toxicity (LD50) comparable to Valdicoxib® as reference anti-inflammatory drugs.
