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Articles by Hasan S. Yusufoglu
Total Records ( 5 ) for Hasan S. Yusufoglu
  Ahmed I. Foudah , Aftab Alam , Gamal A. Soliman , Mohammed Ayman Salkini , Elmutasim O. Ibnouf Ahmed and Hasan S. Yusufoglu
  The study was designed to investigate the pharmacognostic parameters of the aerial parts as well as antimicrobial and antioxidant activities of methanol extract of Pulicaria somalensis O. Hoffm (MEPS). These studies were carried with a view to justify the future use of this plant. This study deals with the morphological, microscopical studies of leaf, aerial part of P. somalensis, along with the physicochemical and preliminary phytochemical analyses that were also studied. The antibacterial activities were tested against both Gram-positive and Gram-negative bacteria while antifungal activities were tested against Aspergillus niger and Candida albicans using the agar disc diffusion method. The zone of inhibition was compared with standard (Ampicillin). The study of in vitro antioxidant was performed by using DPPH and FRAP assays. The results of the present morphological study correlated with earlier reports. The microscopical and physicochemical finding explores the useful identification character for authentication of this plant. The preliminary phytochemical study showed the presence of phenol, tannins and flavonoids types of active drugs. The marked antibacterial, antifungal and antioxidant were observed, which may be due to the presence of active constituents present in MEPS. The outcome of the present findings suggested that the plant may be a good source of antibacterial and antioxidant. The present finding concluded the in vitro activities, so it needs to be explored more in vivo evaluation before adding it into the world of medicinal plants.
  Hasan S. Yusufoglu , Gamal A. Soliman , Rehab F. Abdel-Rahman , Maged Saad Abdel-Kader , Majid A. Ganaie , Erdal Bedir , Sura Baykan and Bintug Ozturk
  In the present study, DPPH radical scavenging assay and ferric-reducing antioxidant assay were used to evaluate in vitro antioxidant potential of the methanol extract of Ferula duranii (F. duranii). The antihyperglycemic and antihyperlipidemic activities of F. duranii extract were evaluated in streptozotocin (STZ)-induced diabetic rats. F. duranii showed considerable antioxidant potential in the DPPH radical scavenging assay and minimum reducing power in ferric-reducing antioxidant power assay. A meaningful reduction in the concentrations of Fasting Blood Glucose (FBG), glycosylated hemoglobin (Hb A1c), triglycerides (TG), Total Cholesterol (TC) and Low Density Lipoprotein (LDL-C) in plasma and an elevation in the activity of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) in hepatic and pancreas homogenates were observed in diabetic animals medicated with F. duranii extract in comparison with diabetic control rats. The level of insulin raised significantly in plasma of diabetic groups received F. duranii in respect to diabetic control one. Levels of alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP), bilirubin, total protein and High Density Lipoprotein (HDL-C) in plasma and malondialdehyde (MDA) in liver and pancreas homogenates were recovered significantly in F. duranii-medicated diabetic rats in comparison with diabetic controls. The present data suggest that F. duranii has both antidiabetic and antihyperlipidemic effects.
  Hasan S. Yusufoglu , Gamal A. Soliman , Ahmed I. Foudah , Maged S. Abdulkader , Mohammed H. Alqarni , Aftab Alam and Mohammad Ayman Salkini
  Background and Objective: Arnebia hispidissima (A. hispidissima) a member of the family Boraginaceae, is dye yielding and medicinally important plant. It is widely used in the cosmetic industries. This study has been made for the preliminary standardization of A. hispidissima plant. Methodology: The standardization evaluation comprises of powder microscopy and fluorescence analysis and TLC profiling. In addition, preliminary phytochemical screening, determination of total phenol and in vitro free radical scavenging activity (DPPH radicals scavenging assay and reducing power activity) were preformed utilizing the methanol extract. Results: A microscopic study of powder of whole plant of A. hispidissima showed different types of trichomes, vessel and fibres. Fluorescence analysis showed different colours under visible light, low UV and high UV. TLC of the hexane extract developed 8, 6, 9 and 10 spots with visible light, low UV, high UV and ninhydrin-H2SO4 spray, respectively. The phytochemical analysis of the methanol extract gave a positive indication for the presence of active compounds including alkaloids, carbohydrates, glycosides, steroids, triterpenoids saponins, phenols, tannins, flavonoids and proteins. The quantitative analysis showed the presence of a significant quantity of total phenol and the in vitro antioxidant activity clearly showed the terrific antioxidant property. Conclusion: The data generated from the present study can be utilized for the identification and quality control of A. hispidissima plant.
  Hasan S. Yusufoglu , Gamal A. Soliman , Ahmed I. Foudah , Maged S. Abdulkader , Hossny A. El-Banna , Aftab Alam and Mohammad Ayman Salkini
  Background and Objective: Arnebia hispidissima (F. Boraginaceae) has been found to have cardiac and febrifuge properties. It has long been used in traditional system of medicine for the treatment of heart ailments, headache and fever. This study aimed to investigate the protective effect of Arnebia hispidissima extract (AHE) on carbon tetrachloride (CCl4)-induced cardiotoxicity and nephrotoxicity. Materials and Methods: Adult rats were divided into five groups and medicated as follows: (1) The control group received the vehicles (olive oil; 1 mL kg–1, i.p.+3% Tween 80; 1 mL kg–1, p.o.). (2) CCl4 group of animals was administered with 20% CCl4 in olive oil (1 mL kg–1, p.o.). (3) Silymarin group was co-administered with CCl4 plus silymarin (50 mg kg–1, p.o.). (4) CCl4 plus AHE (200 mg kg–1, p.o.). (5) CCl4 plus AHE (400 mg kg–1, p.o). Rats received vehicle, CCl4, silymarin or AHE twice a week for 8 weeks. Serum AST (aspartate transaminase), LDH (lactate dehydrogenase), CK (creatine kinase), CK-MB (creatine kinase-MB isoenzyme) and cTnI (cardiac troponin) were measured to assess the heart damage markers. Serum levels of creatinine, urea, uric acid and BUN (blood urea nitrogen) were measured as markers of the renal function. Markers of oxidative stress in the cardiac and renal tissues were estimated by determining the levels of SOD (superoxide dismutase), GPx (glutathione peroxidase), CAT (catalase), GSH (reduced glutathione) and MDA (malondialdehyde). Heart and kidney tissues were investigated for histopathological changes. Results: Administration of CCl4 significantly increased the levels of cardiac and renal damage markers. Co-administration of CCl4 plus AHE significantly relieved the adverse effect of CCl4 in rat and reduced the increased serum levels of cardiac and renal damage markers. AHE compensated the deficits in the antioxidant defense mechanisms (SOD, GPx and CAT) and suppressed LPO (lipid peroxidation) in rat heart and kidney resulting from CCl4 administration. Moreover, histopathological changes induced with CCl4 in heart and kidney tissues of rat were also reduced with the co-administration of AHE. Conclusion: In this study, we have found that oral administration of AHE prevented CCl4-induced cardio- and nephrotoxicity by accelerating heart and kidney antioxidant defense mechanisms and down regulating the LPO near to the normal levels.
  Hasan S. Yusufoglu , Gamal A. Soliman , Rehab F. Abdel- Rahman , Maged Saad Abdel-Kader , Majid A. Ganaie , Erdal Bedir , Sura Baykan Erel and Bintug Ozturk
  The present study was carried to explore the potential antihyperglycemic and antihyperlipidemic activity of Ferula assa-foetida L. and Ferula tenuissima Hub-Mor & Pesmen extracts in streptozotocin (STZ) induced diabetic rats. Furthermore, phytochemical screening, in vitro antioxidant activity and acute toxicity study of both plants were performed. Both extracts showed considerable antioxidant potential in vitro. In diabetic rats, F. assa-foetida (200 and 400 mg kg–1) and F. tenuissima (400 mg kg–1) showed significant elevation in plasma insulin level, total hemoglobin (Hb) and decrease in Fasting Blood Glucose (FBG) and glycosylated hemoglobin (HbA1c) levels. Significant elevations in the activities of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and level of reduced glutathione (GSH) in liver and pancreas homogenates were observed in diabetic animals following F. assa-foetida (200 and 400 mg kg–1) and F. tenuissima (400 mg kg–1) treatments. The antihyperlipidemic effect of F. assa-foetida extract was demonstrated by a significant reduction in plasma triglycerides (TG), Total Cholesterol (TC), Low Density Lipoprotein Cholesterol (LDL-C) and the increase of High Density Lipoprotein Cholesterol (HDL-C). Plasma activities of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) and levels of Total Protein (TP) and bilirubin (BIL) in diabetic rats were recovered significantly after F. assa-foetida and F. tenuissima treatment in comparison with diabetic controls. The present data suggest that F. assa-foetida have both antihyperglycemic and antihyperlipidemic effects with enhancement of insulin-secreting activity.
 
 
 
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