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Articles by Harun Alp
Total Records ( 3 ) for Harun Alp
  Ismail Aytekin , Harun Alp , Nuri Mamak and Savas Aslan
  Study material consisted as 15 experiment and 8 control, totally 23 cattle that possessed by 2 breeders and together housed in Afyonkarahisar province, Suhut district, Kilickaya village; despite vaccine used two times for medicinal purpose displaying no recovery; aged at between 3 and 12 months, diagnosed as dermatofitosis by clinically and microbiological. Being clinical for dermatofitosis the animals in experiment and control groups were examined if there were lesions on the head and derm or not and was categorized as light, bland and acute according to its frequency. The clinical status were examined according to the localization, amplitude and number of lesions. During the study any change was done in condition of animal care, nutrition and shelter. The experiment group was made up 15 cattle; two of them were examined as light, five of them were examined as bland and eight of them were examined as acute and the control group was made up 8 cattle; one of them was examined as light, third of them were examined as bland, fourth of them were examined as acute. Ten percent Enilconazole solution was applied in 4 mg kg-1 dose three days apart as externally to the animals in experiment group. The first application to entire body of the animal and the subsequent 4 applications were done externally in the style of spray to the parts where the dermatofitosis lesions were appeared. The cattle in the control group weren’t applied any therapy. Following the drug administration, in second and fourth weeks a decrease in the keratinized tissues and becoming pilosity were observed in the lesional parts in all experiment group animals. It was seen in the 6th week that keratinized tissues completely decreased, pilosity became dense and the healing was faster. It was determined in the 8th week that lesions recovered completely. It was seen that when any application was made to the control groups animal there were no change in dermatofitosis lesions. As a result, it was of the opinion that owing to easy using, being curative in a short time and being economic of the 10% enilconazole solution was a useful and an alternative medicine for the dermatofitosis therapy in the cattle.
  Ferhan Yaman , Sevda Soker , Serhat Atilgan , Behcet Erol , Harun Alp , Serkan Kamil Agacayak , Ahmet Gunay , Bayram Ince and Mehmet Dalli
  To investigate the effects of Sildenafil on dental tissue. The study was performed with adult female Wistar-Albino rats. Control group (n = 7) were fed on standard laboratory diet until surgery. The study group (n = 7) were administered Sildenafil orally with orogastric tube 10 mg kg-1 once a day for 30 days. Each rat was anesthetized and mandibular bone with incisor teeth and soft tissue were removed. Dental pulp, dentin, periodental ligament, periodental soft tissue and bone were examined histologically. Neovascularization on the dental pulp and gingiva were significantly higher in the study group. Sildenafil can be used as a supporting factor in dental tissue healing.
  Harun Alp , Ismail Aytekin , Onur Atakisi , Namik Kemal Hatipoglu , Kemal Basarali , Metin Ogun , Sadik Buyukbas , Levent Altintas , Husamettin Ekici and Ayse Alp
  The aim of this study was to investigate the effects of Caffeic Acid Phenethyl Ester (CAPE) and Ellagic Acid (EA) on acitivities of Malondialdehyde (MDA), reduced Glutathione (GSH) and Nitric Oxide (NO) in rat lung, liver and kidney tissues in acute Diazinon (DI) toxicity. Six groups of 6 Sprague Dawley rats were used comprising control, CAPE, EA, DI control, DI+CAPE and DI+EA. Tissue samples were analysed for GSH, MDA and NO levels in lung, liver and kidney tissues. Biochemical parameters were measured colormetrically by spectrophotometer. Control, CAPE and EA groups showed no statistically significant difference whereas DI+medication groups revealed that CAPE and EA increased the level of GSH in liver tissue by blocking the DI effect. NO levels in lung, liver and kidney tissues were significantly increased by DI but CAPE and EA attenuated those levels. In DI+medication groups, MDA levels showed no significant change in kidney and liver tissues but in lung tissues, CAPE and EA reduced the MDA level by blocking the DI effect. It was concluded that CAPE and EA which showed similar effects to each other could be used for protection and support against oxidative stress caused by acute DI intoxication.
 
 
 
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