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Articles by Haq Nawaz Bhatti
Total Records ( 11 ) for Haq Nawaz Bhatti
  Aamira Iqbal , Haq Nawaz Bhatti , Sofia Nosheen , Amer Jamil and Muhammad Ashraf Malik
  Present study shows the complexity of determining the chemical composition of three exopolysaccharides obtained from bacteria associated with plant roots grown under salt stress conditions. Physicochemical analysis indicated that the exopolysaccharides were varying in their chemical composition. Presence of the sugar shows that these were hetero/homo polysaccharides. IR analysis of the crude extracts for the presence of functional groups indicated a need for more purification of exopolysaccharides. Moreover the IR analysis along with histochemical studies showed the presence of hydroxyl, carboxyl and nitro groups. The physicochemical characteristics of the exopolysaccharides showed that the exopolysaccharides would be used in industrial applications. However, a thorough investigation is needed to determine their industrial application.
  Sumera Saeed , Haq Nawaz Bhatti and T. M. Bhatti
  The bioleaching behavior of rock phosphate (Jordan imported) was studied using different strains of Aspergillus niger (567, 1737 and NRRL 605). X-ray diffraction analysis revealed the presence of fluorapatite [Ca2(PO4)3F] as the main source of phosphorus (P). Average content of phosphorus in test ore was 33.6% Scanning electron microscope showed the presence of significant amount of phosphorus (P). Decrease in pH was observed due to organic acids produced by Aspergillus niger strains during growth on liquid media containing glucose. Maximum of 30% P O and 34% U O was solubilized having rock phosphate pulp density 2%.
  Nosheela Ambreen , Haq Nawaz Bhatti and T.M. Bhatti
  The research work deals with the examination of the dissolution of aluminum from low grade bauxite of pail deposits (Khushab) with different penicillium strains. X-ray diffraction data indicated the presence of silicate and aluminosilicate minerals. Scanning electron microscopy and electron disperse X-ray analysis showed the presence of aluminum iron silica and titanium. Decrease in pH in the range of 3.40 was observed in liquid growth media inoculated with Penicillium strains (Penicillium simplicissimum and Pinicillium sp. UAF1) due to the production of organic acids. About 4.6 g l-1 Al2O3 was solubilized having bauxite pulp density 5%.
  Bushra Majeed , Haq Nawaz Bhatti and Kouser Fatima
  Acetylsalicylic acid is unique among the Non-steriodal Anti-Inflammatory Drugs (NSAIDs) in irreversibly acetylated cyclooxygenase. Renal clearance of endogenous creatinine and salicylate (as free salicylic acid) was investigated in twelve healthy female volunteers after oral dose of 600 mg soluble aspirin. Blood and urine samples were collected at predetermined time intervals. The concentration of free salicylic acid and creatinine in plasma and urine was determined colorimetrically. The average ±SE values, for free salicylic acid in plasma was 25.569±0.60 and in urine was 37.892±4.537 μgmL–1, for diuresis 0.034±0.005 mlmin–1kg–1, concentration of creatinine in plasma was 14.16±0.55 and in urine was 493.22±62.5 μgmL–1, renal clearance of creatinine was 1.438±0.30 and free salicylic acid was 0.082±0.016 mlmin–1kg–1 and clearance ratio was 0.092±0.023. It was found that renal clearance of aspirin was low under indigenous conditions.
  Kouser Fatima , Haq Nawaz Bhatti and Bushra Majeed
  Urinary excretion of acetylsalicylic acid (aspirin) as free Salicylic Acid (SA) was observed in 12 healthy young female volunteers. After oral administration of 600 mg of drug (ASA) urine samples were collected at predetermined time intervals. Mean±SE value for pH of urine in this study was 6.04±0.14, diuresis was 0.029±0.005 mLmin–1 kg–1, concentration of free Salicylic Acid (SA) was 44.66±0.389 μg mL–1. Mean ±SE value for rate of excretion was 1.087±0.247 μg min–1 kg–1, amount excreted was 6.445±1.188 mg and percentage dose excreted was 1.076±0.197 percent. The mean ±SE value for the cumulative amount excreted was 20.85±2.708 mg and percent cumulative amount excreted was 6.45±0.64 percent. The results indicated that there was low urinary excretion under indigenous conditions.
  Misbah Sultan , Haq Nawaz Bhatti and Zafar Iqbal
  The present project was undertaken to evaluate the quality of ginger rhizomes imported from China and Thailand, on the basis of their essential oil content and composition. Essential oil of two ginger rhizomes imported from China and Thailand was extracted by hydro distillation. Essential oil content was found to be 0.98 (China) and 1.58% (Thailand). Chemical analysis of essential oil was carried out by GC-FID. Essential oil of Thailand ginger sample contained α-pinene 3.59, α-phallendrene 2.84, myrecene 4.58, β-pinene 0.74, γ-terpinene 2.49, 1, 8-cineol 3.87, citral 5.39 and zingibrene 30.81%. Essential oil of China ginger sample contains α-pinene 0.305, α-phallendrene 1.02, myrecene 4.82, γ-terpinene 2.88, 1, 8-cineol 2.4, α-terpinene 6.5, citral 4.5 and zingibrene 8.0%. Ginger sample from Thailand was found to be better in quality due to higher percentage of essential oil (60%).
  Umer Rashid , Haq Nawaz Bhatti , Muhammad Asif Hanif and Najum Rasheed Ahmad
  Urinary excretion of Salicyluric acid (SUA) was investigated in twelve healthy male volunteers. Urine sample was collected up to 10 h. The concentration of salicyluric acid (SUA) a major metabolite of aspirin was measured colorimetrically. The concentration of salicyluric acid (SUA) (mean±SE) in urine was 200.5±14.9 μg mL-1. Excretion of salicyluric acid was extremely variable and depends upon pH of urine. The results show that the mean±SE values for pH of the urine was 6.24±0.11, amount of drug excreted as salicyluric acid was 63.5±12 mg and percentage of dose excreted was 10.66±1.98. The cumulative amount of dose excreted as salicyluric acid was 191.3±58.2 mg and cumulative percent of dose excreted as salicyluric acid was 62.45±1.06. There is statistically slight variation in urinary excretion of SUA data when compared with foreign investigated values.
  Imrana Naseem and Haq Nawaz Bhatti
  Studies were conducted to investigate the effect of organic matter arid salt concentration on cation exchange equilibria In non-calcareous soils. Various physico-chemical properties like pHs, ECe, soluble ions, exchangeable cations, ESP, SAFI, lime and organic matter were determined. In homovalent (K+-Na+) exchange, the values of Kk increased with increasing organic matter. The results of three levels of salt concentration indicated that equal concentration of both the salts showed less coefficient values es compared to 1:2 K+-Na+ concentration, but this coefficient values markedly increased by 2:1 K+-Na+ concentration. In heterovalent (K+-Ca2+) exchange, selectivity coefficients showed an increase with increasing organic matter, while in case of salt concentration, 2:1 ratio had marked effect on Kk, Ky and KG values.
  Bazghah Sadaf Siddiqui , Haq Nawaz Bhatti , Ambreen Ijaz , Saba Rasheed and Bushra Saleem
  Acetylsalicylic acid is a non-steroidal anti-inflammatory drug. Urinary excretion of ASA (as free salicylic acid) was investigated in twelve healthy male volunteers after an oral administration of 600 mg dose. Urine samples were collected upto 10 h. The concentration of drug was determined colorimetrically and mean ±SE value in urine was found to be 37.55±0.418 μg mL–1. The values for diuresis and rate of excretion was 0.028±0.006 mL min–1 kg–1 and 0.849±0.226 μg min–1 kg–1. The amount of free SA excreted was 5.40±1.15 mg. The % dose excreted was 0.92±0.19%. Cumulative amount and % cumulative dose excreted was found to be 17.74±2.91 mg and 5.47±0.78%. There is slight variations in urinary excretion data when compared with foreign investigated values.
  Saba Rashid , Haq Nawaz Bhatti , Ambreen Ijaz , Bazgha Sadaf and Sarfraz Ahmed
  Renal clearance of endogenous creatinine and acetylsalicylic acid was investigated in 12 healthy male volunteers. Blood and urine samples were collected at pre-determined time intervals. The concentration of acetylsalicylic acid (as salicylates) and creatinine in plasma and urine were determined colorimetrically. Mean ±SE values were found to be, for diuresis 0.031±0.011 mLmin‾1 kg–1, Plasma concentration of creatinine and salicylic acid 15.11±0.166 μg mL–1 and 29.38±0.12 μg mL–1, urine concentration of creatinine and salicylic acid 855.73±1.53 μg ml–1 and 38.30±0.43 μg mL–1, renal clearance of creatinine and salicylic acid 1.52±0.08 ml min–1 kg–1 and 0.063±0.02 mL min–1 kg–1 and clearance ratio 0.054±0.016. The results indicated that there is less renal clearance of acetylsalicylic acid in local environment when compared with values given in literature.
  Ambreen Ijaz , Haq Nawaz Bhatti , Saba Rasheed , Bazghah Sadaf and Rakhshanda Nawaz
  The pharmacokinetics of acetylsalicylic acid, a non-steroidal anti-inflammatory agents, was studied in twelve healthy young females after oral administration of 600 mg aspirin. Blood samples were collected at pre-determined time intervals. The concentration of aspirin as free salicylic acid was analyzed colorimetrially at 530 nm and mean ±SE value in blood was found to be 30.33±0.63 μg mL–1. Individual pharmacokinetic parameters were estimated by using two compartment open model. Mean±SE values were found to be Cmax 44.54±0.46 mg L–1, tmax 1.87±0.05h, t1/2α 1.17±0.25 h, Ka 0.85±1.12 h–1, AUC 275±2.73 h.mg L–1, Vd 10.90±0.76 L, t1/2β 4.69±0.55 h and TBC 1.68±0.06 L h–1. ASA values established in this study were in agreement with those reported by other authors.
 
 
 
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