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Articles by Hannah R. Vasanthi
Total Records ( 2 ) for Hannah R. Vasanthi
  K.S. Vidyalakshmi , A.I. Charles Dorni , Hannah R. Vasanthi , G.V. Rajamanickam and D. Sukumar
  The flowers of Mussaenda glabra occurring in white and pink have been evaluated for their anti oxidant property. The white (MGW) and the pink (MGP) varieties showed considerable NO scavenging activity. The IC50 values were found to be 92.79 and 122.45 μg mL-1, respectively. MGW inhibited lipid peroxidation to a greater extent when compared to MGP. MGW showed 50% inhibition at the concentration of 112.4 μg mL-1 while MGP at 53.42 μg mL-1. The reducing power was found in a dose dependent manner. The pink variety showed greater reducing power when compared to white variety. Both the extracts showed hydroxyl radical and ABTS radical scavenging property. The total phenolic content was 17.5 and 8.3 mg g-1 in MGP and MGW, respectively. The HPTLC fingerprinting showed peaks due to flavonoids. The results show that both are having considerable anti oxidant property. The abundance of this flower throughout the year can be used for evaluating its medicinal value.
  K.S. Vidyalakshmi , A.I. Charles Dorni and Hannah R. Vasanthi
  Mussaenda queensirkit (MQ), an ornamental plant grown in tropical countries is shown to exhibit cytotoxic property. The 70% methanolic extract of fresh flowers of Mussaenda queensirkit (MQF) was studied for its cytotoxic and anti-mitotic activity with Brine Shrimp Lethality assay and Allium cepa Root Tip mitosis experiment, respectively. The LC50 value for MQF was found to be 83.33 μg mL-1 in Brine Shrimp Lethality Assay. The extract showed maximum anti-mitotic activity at the highest concentration studied (2000 μg mL-1) with a mitotic index of 9.0. In the MTT Assay for cytotoxic activity, MQF at 500 μg mL-1, showed a maximum of 71.44% inhibition against fibroblast cultured from skin compared to control whereas the standard, quercetin (50 μg mL-1) exhibited a maximum of 92.7% inhibition. The HPLC profile obtained had characteristic peaks due to flavonol glycosides which might be responsible for the observed cytotoxic and anti-mitotic activity of MQF. The observed cytotoxic and anti-mitotic activity of the extract shows the potential of the plant in the exploration of anti-cancer molecules.
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