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Articles by Hanna Goenawan
Total Records ( 3 ) for Hanna Goenawan
  Iwan Setiawan , Lovita Adriani , Zakiaturrahmi , Hanna Goenawan , Vita Murniati Tarawan and Ronny Lesmana
  Background and Objective: Soy yogurt is fermented soy milk and its nutrient-rich with isoflavones. Soy yogurt decreases blood glucose levels by utilizing the conversion of isoflavones. This study aimed to analyze the effect of soy yogurt on blood glucose level and Glut4 gene expression on rats' soleus muscle. Materials and Methods: Twenty-five rats (eighteen-weeks old) were divided into 5 groups, e.g., the control (P0), positive control (P1, 100% yogurt) and three treatment groups (P2, 50% soy yogurt+50% yogurt; P3, 75% yogurt+25% soy yogurt and P4, 75% soy yogurt+25% yogurt). All treatment groups were treated with different soy yogurt formula and administered for 12 weeks by gavaging. Under anesthetized, rats were sacrificed, then blood samples and soleus muscle were collected and stored at -80°C until use. RNA was extracted from soleus muscle and run for Glut4 mRNA expression using (RT)-PCR. Data were analyzed using one way ANOVA and followed by post hoc test LSD (Least Significant Differences test). Results: There is no difference in rat body weight among groups after 12 weeks of soy yogurt consumption. Blood glucose levels were decreased at least 25% lower level compared to the control baseline by the various formulation of soy yogurt. Interestingly, there is a distinct pattern of Glut4 mRNA expression level in the soleus muscle, P1 increased the expression but not with other formulations decreased the expression (P2, P3 and P4). Conclusion: Taken together, a different formulation of soymilk and cowmilk effectively reduces blood glucose level and modulates Glut4 mRNA expression. In addition, a specific combination of bacteria type for fermenting soy yogurt could be a key to effectiveness for modulating blood glucose levels.
  Ronny Lesmana , Susianti , Todia Pediatama , Nova Sylviana , Yuni Susanti Pratiwi , Hanna Goenawan and Unang Supratman
  Background and Objective: The natural bioactive compounds of Curcuma longa, known as curcuminoids, has been shown to exerts anticancer effects to diverse cancer cell line in vitro, including breast cancer cell line. These curcuminoids consist of curcumin (Cur), demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). Furthermore, there has never been a study to compare the extent of antiproliferative and apoptotic modulation potential between Cur, DMC and BDMC in the breast cancer cell, until now. In the present study, we explore the efficacy among Cur, DMC and BDMC to alters MCF-7 cell viability, which might lead to apoptotic modulation. Materials and Methods: This kind of study was performed in vitro whereby the cells were maintained in an appropriate medium and the anticancer effect of curcuminoids (Cur, DMC and BDMC) was measured by using resazurin-based PrestoBlue cell viability assay. Later, MCF-7 breast cancer cells were cultured in 12 wells plate added with different concentrations of Cur, DMC and BDMC for western blotting analysis. Statistical analysis was performed with GraphPad 8, One-way ANOVA and Student’s t-test. Results: The result showed that Cur, DMC and BDMC inhibiting the proliferation of MCF-7 cells. In the concentration dose of 31.25 μg mL1, the cell viability in cells treated with Cur is 27%, DMC is 31.5% and BDMC is 46%. The IC50 dose of Cur, DMC and BDMC were 25.63, 29.94 and 36.91 μg mL1. Conclusion: Cur is more effective in inhibiting proliferation and apoptotic modulation in MCF-7 cells compare to DMC and BDMC. It represents the potential of Cur, DMC and BDMC as adjunctive therapy in treating breast cancer.
  Vita Murniati Tarawan , Siti Nur Fatimah , Titing Nurhayati , Mohammad Rizki Akbar , Putri Teesa Radhiyanti , Ambrosius Purba , Ieva Baniasih Akbar and Hanna Goenawan
  Background and Objective: Metabolic syndrome (MetS) prevalence is rising globally, especially in the higher educational community, such as university academic staff. The MetS risk factor is unbalanced nutritional intake combined with insufficient physical activity. Therefore, our goal is to examine the effects of gender, age, nutrient intake and physical activity on hypertension, central obesity and hypertriglyceridemia probability as an important component of MetS among university academic staff. Methodology: The method of this study was a cross-sectional survey and physical examination of MetS on 210 academic staff from Universitas Padjadjaran, Bandung, Indonesia, in 2017. Body height was measured with a stadiometer. Nutritional status and fat mass were measured with a Tanita Bioimpedance Analyzer (BIA). The nutrition intake analysis applied a repeated 24 h food recall method. Physical activity was assessed using the Young Men’s Christian Association (YMCA) step test and Global Physical Activity Questionnaire (GPAQ). Triglyceride level was evaluated by the glycerol-3-phosphate oxidase-phenol aminophenazone (GPO-PAP) method. The data were analyzed with chi-square or Fisher’s exact test and a logistic regression test. Results: Analysis findings showed a significant association between gender, age and nutritional status, with 72% probability of hypertension; a significant relationship among gender, age, nutritional status, fat mass and physical fitness, with 98% probability of central obesity; and an association among gender, age and physical fitness, with 4.9% probability of hypertriglyceridemia. Conclusion: These results suggest that middle-aged males who are more than 35 years old, combined with over-nutritional status, less dietary intake, less physical activity and low physical fitness have a higher risk of developing MetS.
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