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Articles by Hanifi Korkoca
Total Records ( 2 ) for Hanifi Korkoca
  Banu Bayram , Harun Onlu , Hanifi Korkoca and Nilufer Selcuk
  In this study, ethanol, water, methanol and acetone extracts of Tulipa sintenisii (Baker) were tested for in vitro antimicrobial activity using disc diffusion method. All of the extracts exhibited antimicrobial effect on Staphylococcus auresus (ATCC 6538), Escherichia coli (ATCC 25922) and Pseudomonas syringae pv. Tomato (DSM 60407 (DSMZ)). While streptomycin (10 μg) which is used for control generates a zone diameter of approximately 15 mm against test microorganisms, it is ascertained that acetone extract generates an inhibition zone diameter of 10.5 mm against Staphylococcus auresus, 12 mm against Escherichia coli and an inhibition zone diameter of 14 mm against Pseudommonas syringae pv. tomato. As a result of the study, it can be said that the extracts of Tulipa sintenisii involves antimicrobial substances against the microorganisms which are used for this study. However, much more complicated researches are needed.
  Ragip Adiguzel , Nevin Turan , Kenan Buldurun and Hanifi Korkoca
  Background and Objective: Saccharin and saccharinate (sac) complexes and its anion have critical importance with biological, biochemical and pharmacological properties. The main objective of this study was to synthesize the novel mixed ligand complexes from the complexes [M(Sac)2(H2O)4]·2H2O [M: Mn(II), Co(II), Ni(II), Cu(II) and Cd(II)] with a second neutral ligand [L:(mmppa): 5-Methyl-4-(4-methylphenylazo)-2H-pyrazole-3-ylamine]. Methodology: The structures of the complexes were characterized by elemental analysis, magnetic susceptibility, FT-IR, mass and electronic spectral studies and thermal analysis. Antimicrobial (antibacterial and anticandidal) activities of the complexes were tested against Enterococcus faecalis ATCC 51299, Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 700603 and Candida albicans ATCC 64548. Results: According to the experimental results, it was determined that in Mn(II), Co(II) and Cd(II) complexes, two coordinated H2O molecules are replaced with two neutral ligands, on the other hand, in Ni(II) and Cu(II) complexes, all coordinated H2O molecules are replaced with four neutral ligands. It was established that the second neutral ligand was coordinated to the metal ions via nitrogen atom of -NH2 group in pyrazole ring. In antimicrobial activity, study was determined to occur significant inhibition zones (20-24 mm) against Candida albicans ATCC 64548 strain. Conclusion: As a result, mononuclear and monomeric structure in octahedral geometry including both saccharin and azo dye ligands were synthesized and their characterizations were accomplished. The result of this study shows that novel mixed ligand-saccharinate complexes can be utilized for the development of anticandidal agents.
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