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Articles by Hanafy A. Hamza
Total Records ( 5 ) for Hanafy A. Hamza
  Khalid Abd EL Ghany , Ekbal Abd Elhafez , Ragaa A. Hamouda , Hoda Mahrous , Fattah Allah H. Ahmed and Hanafy A. Hamza
  Probiotic bacteria are considered beneficial microorganisms and have been widely used. They protect against harmful bacteria that can cause diseases. This study was carried out to evaluate the potential for L. acidophilus intact cells and cell lysates as antioxidant activities and also to evaluate the potential of this bacteria and their exopolysacchariedes (EPS) as antitumor activity in vitro and in vivo against Ehrlich Ascites Carcinoma (EAC) cell line. Lactobacillus acidophilus demonstrated having antioxidant activities for both cell lysates and intact cells with increasing antioxidative properties for cell lysates against 2, 2--diphenyl-1-picrylhydrazyl (DPPH), also resistance to hydrogen peroxide and hydroxyl radical. The EPS produced by L. acidophilus showed a powerful antitumor effect in vivo and in vitro in comparison with L. acidophilus itself while, E. coli increasing solid tumor volume than control.
  Shymaa Kamal , Ragaa A. Hamouda , Hoda Mahrous , Mohammed Labib Salem , Hanafy A. Hamza and Ekbal Abd Elhafez
  Increase in the levels of cholesterol is harmful, it is a risk factor for cardiovascular disease. This study was carried out to compare the in vitro anti-hypercholesteremia effects of different concentrations of probiotic bacteria (lactobacillus casei and lactobacillus plantarum) and cyanobacteria (Spirulina platensis) isolated as intact cells or cell lysates. The results showed that S. platensis is more effective The mixture of cell lysates from L. casei, L. plantarum and Spirulina platensis lowered the level of cholesterol by 65% as compared to the inhibitory effect of L. casei (32%), L. plantarum (33%) and S. platensis (47%). Their significant differences by using the mixture of testing bacteria as intact cells and cell lysate in the percentage of cholesterol reduction.
  Khalid Abd El Ghany , Ragaa A. Hamouda , Hoda Mahrous , Ekbal Abd Elhafez , Fath Allah H. Ahmed and Hanafy A. Hamza
  Background: Lactic Acid Bacteria (LAB) have great therapeutic and nutritional benefits. Among these are: Improved nutritional value of food, control of intestinal infections, improved digestion of lactose, immune modulator effect, control of some types of cancer and control of serum glucose level. Objective: The aim of this study was carried out to evaluate the therapeutic effect of β-glucan extracted from LAB was isolated from different food sources in Egypt. Materials and Methods: The isolation was performed from local Egyptian boza, cider, cheese and yoghurt. Only seven species from 27 was identified as LAB. Only one showed to produce β-glucan and identified by VITEC® 2 as Pediococcus parvulus . The optimization of isolate growth was examined in different temperature, pH and media. Results: The study revealed that the optimum temperature was 37°C, pH was 6 and the most selective medium for growth was Pediococcus selective medium (PSM). Beta-glucan production was assessed by FT-IR analysis, HPLC and HNMR spectroscopy. The therapeutic effect of Pediococcus parvulus β-glucan as antioxidant against DPPH was more significant, cholesterol lowering effect of β-glucan gave valuable results compared to simvastatin drug, the antibacterial effect and control of cancer in vitro against Ehrlich Ascites Carcinoma (EAC) were also gave valuable results. Conclusion: The extracted β-glucan from Egyptian Pediococcus parvulus had different therapeutic effect in vitro including, antioxidative properties, antimicrobial, control of cancer and cholesterol lowering effect.
  Badr E. El Bialy , Ragaa A. Hamouda , Khaled S. Khalifa and Hanafy A. Hamza
  Objective: This study aimed to evaluate the potential anti-cancer effect of silver nanoparticles (AgNPs, of 8-16 nm size range) biosynthesized from Turbinaria turbinata marine-alga against Ehrlich Cell Carcinoma (ECC) in mice. Materials and Methods: After 1 day of s/c Ehrlich cells inoculation in mice thigh, AgNPs were injected in the same site at doses of 85 and 42.5 μg for each mouse daily for 20 days. Till the end of the experiment, none of clinical signs were observed on mice. Results: The AgNPs induced dose-dependent reduction in tumor size. The cytotoxic insult of AgNPs against ECC referred to its potential oxidative damage effect proved by elevation of MDA and H2O2 contents in tumor tissue and induction of apoptosis via caspase 3 activation. Also, AgNPs brought the elevated white blood cell count in tumor-bearing mice to near-normal range. The histopathological investigation of tumor tissues revealed presence of severe necrosis of cancer cells especially at higher dose of AgNPs. Conclusion: Biosynthesized AgNPs from Turbinaria turbinata could control the growth of ECC in mice with limited adverse effects.
  Shehab E. Talat , Mahmoud Abd El-Mongy , Mona I. Mabrouk , A.B. Abeer Mohammed and Hanafy A. Hamza
  Background and Objective: β-lactam resistant bacteria are emerging highly drug-resistant causing infections accompanied with significant importance. This study was undertaken to detect the β-lactam antibiotic resistant P. aeruginosa obtained from edible foods in El-Giza governorate, Cairo, Egypt and role of the plant oils in reducing β-lactam resistance for P. aeruginosa . Fifty samples from edible food were collected from supermarkets. There are multi drug resistant bacteria presented in the tested edible food. Materials and Methods: Isolation were carried out using classical method by using selective medium then the isolates were identified using modern techniques by PCR and DNA sequencing techniques. Results: Results showed identified isolates were 50 pathogenic bacteria as Staphylococcus spp., 10 isolates (40%), Micrococcus spp., 1 isolate (4%), E. coli 11 isolates (44%), Citrobacter freundii 1 isolate (4%), Enterobacter species 1 isolate (4%), Enterobacter cloacae 1 isolate (4%) and P. aeruginosa 1 isolate (4%). The P. aeruginosa strain was resistance to piperacillin/tazobactam and meropenem, intermediate to gentamicin while sensitive to amikacin, levofloxacin and ciprofloxacin. Moreover, P. aeruginosa strain was sensitive to thyme oil but resistant to fennel, caraway and peppermint oils. Conclusions: Results concluded that treatment β-lactam resistant P. aeruginosa by aminoglycosides or fluoroquinolones antibiotics has significant value. Also, thyme oil considered one of the most important oils in the antimicrobial aspects. Finally treatment of resistant strain of P. aeruginosa by combination of antibiotic and medicenal plants even if resistant to these oils has significant potentiating effect.
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