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Articles by Hala F. Zaki
Total Records ( 3 ) for Hala F. Zaki
  Sally A. El-Awdan , Hala F. Zaki , Omar M. Abdel Salam , Wafaa I. El-Iraqy and Sanaa A. Kenawy
  The present study aim to explore the impact of bromocriptine, or ziprasidone on rats mucosal integrity and the possible modulation by L-carnitine or ranitidine. Adult male Wistar rats were divided into 10 groups: the 1st and 2nd groups received 1% Tween 80 and served as normal and control groups, respectively. The remaining groups were treated as follows: 3-6 received bromocriptine (2.5 mg kg-1), L-carnitine (50 mg kg-1), ranitidine (50 mg kg-1) or ziprasidone (3 mg kg-1), respectively. Groups 7-10 received combinations of bromocriptine or ziprasidone with either L-carnitine or ranitidine. Drugs were daily administered (p.o.) for two weeks then all groups were subjected to pyloric ligation. Indomethacin (30 mg kg-1; p.o.) was immediately administered to all groups except the normal one. Rats were euthanized 4 h thereafter and stomachs were opened to evaluate the number and severity of the lesions. Gastric volume, acid output, peptic activity as well as mucin and gastric mucus concentrations were determined. Moreover, stomach content of lipid peroxides, reduced glutathione, nitric oxide metabolites and tumor necrosis factor were also estimated. Indomethacin administration resulted in increased ulcer index and severity that was coupled by increased titratable acidity, acid output and disturbance in antioxidant status. Such effects were intensified by ziprasidone and ameliorated by bromocriptine, L-carnitine or ranitidine. Moreover, administration of L-carnitine or ranitidine with ziprasidone attenuated its damaging effect. In conclusion, dopamine agonists play a significant role in maintenance of gastric mucosal integrity; meanwhile, dopamine antagonists complicate indomethacin-induced ulcers, an effect that could be mitigated by combined treatment with L-carnitine or ranitidine.
  Suzan M. Mansour , Hala F. Zaki and Ezz-El-Din El-Denshary
  Objective: Incidence of Metabolic Syndrome (MS) is strongly associated with increased fructose consumption. This study aimed to elucidate the role of rosiglitazone, Chromium Picolinate (CP) and their combination on fructose-induced MS. Materials and methods: Four groups of rats (n = 10) were fed on Fructose-enriched Diet (FED) for 16 weeks. One served as FED-control while the remaining groups were treated with rosiglitazone (4 mg kg-1 day-1), CP (80 μg kg-1 day-1) or their combination during the last 6 weeks. A fifth group was fed on normal diet (normal group). At the end, blood samples were collected for estimation MS-related markers. Results: Histological examination of livers, kidneys and pancreases from all groups was done. Induction of MS was associated with increased weight gain and insulin resistance coupled with elevated levels of blood glucose, insulin, uric acid, urea, creatinine and lipids. FED also reduced plasma catalase and glutathione peroxidase activities parallel to increased serum leptin and TNF-α levels. This was coupled with marked histological changes in the livers, kidneys and pancreases. Treatment with rosiglitazone or CP attenuated most of the changes associated with MS. Besides, combination of both agents further improved disease markers and decreased hepatocytes fibrosis. Conclusion: The present results reveal the benefits of co-supplementation of rosiglitazone and CP in MS.
  Rasha E. Mostafa , Hala F. Zaki , Amany A. Sleem , Omar M. Abdel-Salam , Fatma A. Morsy and Sanaa A. Kenawy
  The study aimed to investigate the effect of pegylated interferon alpha (Peg IFN α2a), standard interferon alpha (Std IFN α2a) and silymarin in liver fibrosis induced in rats by chronic treatment with carbon tetrachloride (CCl4). Rats were divided into 9 groups (n = 7 per group). Group 1 received olive oil (0.5 mL kg-1, p.o. twice weekly) for 8 weeks followed by saline for 4 weeks (normal control). The remaining 8 groups received CCl4 (0.5 mL kg-1, p.o.) twice weekly for 8 weeks, followed by saline (CCl4 control), Std. IFN α2a (1.5 or 3 MIU kg-1, s.c., 3 times per week), Peg IFN α2a (1 or 2 μg kg-1, s.c., once per week), silymarin (100 mg kg-1 day-1, p.o.) alone or combined with either Peg IFN α2a (1 μg kg-1) or Std. IFN α2a (1.5 MIU kg-1), respectively for 4 weeks. At the end of the experiment, blood samples were collected and livers were isolated for biochemical and histological assessment of markers related to liver fibrosis. Administration of CCl4 resulted in increases in liver function tests, liver lipid peroxides and hydroxyproline contents coupled with decrease in total protein and liver content of reduced glutathione. Administration of Peg IFN α2a or silymarin alone or combined together attenuated CCl4-induced changes. On the other hand, using Std. IFN was not coupled by significant improvement in CCl4-induced changes, an effect that was reversed by its combination with silymarin. In conclusion, administration of Peg IFN, silymarin or their combination can limit hepatocellular fibrosis caused by chronic CCl4 administration; whereas, the effects of Std. IFN are only evident when combined with silymarin.
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