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| Articles
by
Hala F. Abdel-Hamid |
Total Records (
1 ) for
Hala F. Abdel-Hamid |
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Tarek M. Heikal
,
Abdel-Tawab H. Mossa
,
Azza W. Ibrahim
and
Hala F. Abdel-Hamid
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Pesticides have contributed for many public health hazards in man including
infertility. So, the present study aimed to assess the protective role of green
tea extract (GT) against the possibility of reproductive toxicity resulting
from chlorpyrifos (CPF), cyromazine (Cyr) and their combination exposure in
mature male Wistar rats. Rats were administered CPF (5.4 mg kg-1
b.wt., 1/25 LD50), Cyr (135.48 mg kg-1 b.wt., 1/25 LD50),
CPF+Cyr, GT (1.5% w/v in water) as the only drinking fluid, CPF+GT, Cyr+GT and
CPF+Cyr+GT daily via gavage for 70 days to complete the spermatogenic cycle.
The results revealed that exposure to CPF, Cyr and CPF+Cyr significantly decreased
the fertility index, weights of sexual organs (testes, seminal vesicles, epidermis
and prostate gland), sperm characteristics (motility and count) as well as serum
testosterone level, while increased sperm abnormality. In addition, the testicular
tissue level of reduced glutathione (GSH) and the activities of superoxide dismutase
(SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase
(GST) enzymes were significantly decreased while increased the level of testicular
tissue lipid peroxidation (LPO) compared with the control group. The testicular
histopathological lesions were characterized by moderate to severe degenerative
changes of seminiferous tubules and incomplete arrest of spermatogenesis. Co-administration
of GT to treated-animals alleviates the reproductive toxicity and testicular
oxidative damage. In conclusion, the use of green tea extract appeared to be
beneficial in attenuating and improving the testicular damage and reproductive
toxicity sustained by insecticide exposure in male rats. |
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