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Articles by Hakan Oner
Total Records ( 2 ) for Hakan Oner
  Jale Oner , Ilter Kus and Hakan Oner
  The purpose of this study was to investigate, whether or not melatonin has a role in the prevention of CCl4-induced hepatotoxicity in rat by means of IGF expression. The animals used in study were grouped as following: Control, CCl-4 injected group and CC4 + melatonin injected group. Tissue samples were examined using immunohistochemistry and obtained data were evaluated statistically. IGF-I expression observed in hepatocytes was weakest in CCl4 injection group. Melatonin administration increased IGF-I expression in hepatocytes. The HSCORE value of the CCl4 injected group was lower than that of other groups. The highest HSCORE value belonged to CCl4 + melatonin injected group. On the basis of the data in the present study, we suggest that melatonin secreted by the pineal gland may have preventative role in hepatic damage by increasing IGF-I releasing.
  Aysel Kukner , Jale Oner , Hakan Oner and Enver Ozan
  The aim of this study was to investigate effect of the vitamin E on changes in Bax and Bcl-2 expression in the rat testes during immobilisation stress. The animals were divided into three groups. The rats in group I were immobilised for 6 h on 5 consecutive days. The rats in group II were daily injected vitamin E (100 mg kg-1) for 5 days during immobilisation. Control rats were allowed to move freely. The percentage of Bax immunpositive spermatogonia in stress group was significantly higher than those in control groups (p<0.05) but Bcl-2 was not significantly (p>0.05). The percentages of Bax and Bcl-2 immunpositive cells in the vitamin E treated group was decreased than the immobilization stress group. It was observed that Bax and Bcl-2 expression were peak level (+) in the spermatogonia of the control group. In this group, Bax and Bcl-2 expression were not determined mostly in the seminifer tubules. Neither Sertoli cells nor spermatids showed immunoreaction. Bax immunoreactivity was observed at strong level (+++) in both spermatogonia and intersititial cells of immobilised rats. In this group, Bcl-2 protein was expressed at peak level (+) in the spermatogonia. Bax expression was decreased in vitamin E treated group and at peak level (+) immunreaction was showed in the spermatogonia and intersitisyal cells. Findings of this study show that the immobilisation stress increases apoptosis and vitamin E decreases Bax and Bcl-2 expression that are apoptosis-releated proteins in the immobilised rat testes.
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