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Substance P (SP) is known to play an important role in bone
mineralization. However, little is known about the potential of substance P
as an osteogenic inducer in human Adipose-Derived Stem Cells (hADSCs) in
vitro. Therefore, the aim of this study to investigate the effects of substance
P on proliferation and osteogenic differentiation of hADSCs in vitro.
Human Adipose-Derived Stem Cells (hADSCs) derived from wasted adipose tissue
in liposuction operation were cultured. Expression of the SP receptor (NK1)
was detected by RT-PCR. Effects of SP on proliferation and differentiation of
hADSCs were studied, moreover alkaline phosphatase activity was also assayed.
It was found that the NK1 receptor was expressed in hADSCs. SP stimulated the
proliferation of hADSCs in a concentration-dependent manner. Higher concentrations
(10G8 M) of SP increased alkaline phosphatase activity and enhanced
differentiated in hADSCs. NK1 receptors are expressed by hADSCs and SP stimulates
osteoblast differentiation and function in vitro. These findings strengthen
the knowledge about the role of SP in hADSCs.
The study aims at investigating the aeolian turbulent environment
around a long-span bridge site in mountainous terrain in western China. Anemometers
were installed over the height of the bridge site to measure both instantaneous
wind speed and direction as well as their means. Turbulence intensity results
showed that, the mean wind speed at the site presented complex variations over
its height,the turbulence intensity at height of 10 m above the arch springing
exceeded 40% and at 90 m it was still as high as 15%. The site’s
wind speed profile did not follow either logarithmic or exponential models.
The measured horizontal turbulent wind speed spectrum was closer to an Irwin
spectrum, but differed from the Simiu spectrum: vertical turbulent wind speed
spectra differed from the Panofsky spectrum.
