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Articles by Haiyan Wang
Total Records ( 3 ) for Haiyan Wang
  Haiyan Wang , Jianhua Cao and Shuhong Zhao
  The porcine Gene Expression Database (PGED) is an open-source web data repository specially for porcine gene expression data. It archives porcine gene expression data in different experiments and associated functional annotation. A user-friendly web interface allows users to browse, retrieve, analyze and visualize data which is intended to facilitate to identify genes of interest and explore their expression profiles.
  Changjun Li , Xiaolan Wu , Xiaojuan Lou , Yajun Wu , Ang Li and Haiyan Wang
  The present study examined the effects of crude Polysaccharide from Gynostemma pentaphyllum (PGP) against oxidative stress induced by swimming exercise. Male rats were administered PGP (50, 100, 200 and 400 mg kg-1) by gavage every day. After 30 days, swimming exercise of rat was performed in acrylic plastic pool. The results showed that PGP treatment prolonged exhaustive swimming time and improved liver glycogen reserve which suggested that PGP treatment influenced the performance of exhaustive exercise and improved exercise tolerance. Moreover, PGP treatment can promote increases in the activities of Super Oxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPH-Px) and reduce lipid per-oxidation which suggest that PGP treatment was beneficial in enhancing the antioxidant status and inhibiting oxidative stress induced by exhaustive exercise.
  Anais Perilhou , Cecile Tourrel-Cuzin , Pili Zhang , Ilham Kharroubi , Haiyan Wang , Veronique Fauveau , Donald K. Scott , Claes B. Wollheim and Mireille Vasseur-Cognet
  Pancreatic islet beta cell differentiation and function are dependent upon a group of transcription factors that maintain the expression of key genes and suppress others. Knockout mice with the heterozygous deletion of the gene for chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII) or the complete disruption of the gene for hepatocyte nuclear factor 4α (HNF4α) in pancreatic beta cells have similar insulin secretion defects, leading us to hypothesize that there is transcriptional cross talk between these two nuclear receptors. Here, we demonstrate specific HNF4α activation of a reporter plasmid containing the COUP-TFII gene promoter region in transfected pancreatic beta cells. The stable association of the endogenous HNF4α with a region of the COUP-TFII gene promoter that contains a direct repeat 1 (DR-1) binding site was revealed by chromatin immunoprecipitation. Mutation experiments showed that this DR-1 site is essential for HNF4α transactivation of COUP-TFII. The dominant negative suppression of HNF4α function decreased endogenous COUP-TFII expression, and the specific inactivation of COUP-TFII by small interfering RNA caused HNF4α mRNA levels in 832/13 INS-1 cells to decrease. This positive regulation of HNF4α by COUP-TFII was confirmed by the adenovirus-mediated overexpression of human COUP-TFII (hCOUP-TFII), which increased HNF4α mRNA levels in 832/13 INS-1 cells and in mouse pancreatic islets. Finally, hCOUP-TFII overexpression showed that there is direct COUP-TFII autorepression, as COUP-TFII occupies the proximal DR-1 binding site of its own gene in vivo. Therefore, COUP-TFII may contribute to the control of insulin secretion through the complex HNF4α/maturity-onset diabetes of the young 1 (MODY1) transcription factor network operating in beta cells.
 
 
 
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