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Articles by Haithum W. Al-Obaide
Total Records ( 2 ) for Haithum W. Al-Obaide
  Mohammed A. Ibrahim , Noha Saleh , Esmael Archoukieh , Haithum W. Al-Obaide , Mohannad M. Al-Obaidi and Harun M. Said
  Molecular genetic studies suggested that genetic instabilities of genomic DNA are implicated in the pathogenesis of cancers. In this study the molecular genomic polymorphism of acute lymphoblastic leukemia was analyzed by 23 arbitrary primers of decamer oligonucleotides to investigate the genetic correlation by cluster tree analysis. Ten primers were able to amplify genomic DNA of leukemia patients, but varied in their ability to detect genomic DNA instability. One of amplifying primers showed novel pattern of amplified DNA fragments. It amplified DNA fragment (3.162 kbp) in normal individuals but was absent in 77.8% of patients, whereas other amplified DNA fragment (0.98 kbp) was absent in normal individuals but it was present in 55.6% of patients. Moreover, dissimilarity matrix analysis of amplified DNA fragments provided genetic relatedness among genomic DNA of patients.
  Mohammed A. Ibrahim , N. Saleh , Khalida M. Mousawy , N. Al-Hmoud , E. Archoukieh , Haithum W. Al-Obaide and Mohannad M. Al-Obaidi
  In this study the molecular genomic polymorphism of age related acute myeloid leukemia was analyzed by twenty one arbitrary primers of decamer oligonucleotides to investigate the genetic polymorphisms. Two categories of RAPD primers were identified, according to their ability to amplify genomic DNA. Thirteen primers were found unable to amplify genomic DNA of acute myeloid leukemia patients. On the other hand, eight primers were able to amplify genomic DNA and were divided into two subgroups, first group showed monomorphic DNA fragments, whereas the second one gave polymorphic bands. One of the polymorphic amplifying primers showed unique patterns of amplified DNA fragments in the genomic DNA of age related acute myeloid leukemia.
 
 
 
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