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Articles by Hai Nguyen Thanh
Total Records ( 2 ) for Hai Nguyen Thanh
  Hue Pham Thi Minh , Hai Nguyen Thanh , Quang Nguyen Tuan , Anh Tran Le and Tung Bui Thanh
  Amphotericin B is a polyene antifungal drug used intravenously for systemic fungal infections. It has severe and potentially lethal side effects, therefore, it has been limited use in clinical. Liposomes are widely used as vehicles to target organ in pharmaceutical technology due to their ability to improve the delivery of drugs, increasing therapeutic efficacy and decreasing toxicity. The aim of this study is to prepare a liposomal amphotericin B by hydration of a thin lipid film and ethanol-injection methods and evaluate its antifungal activity in vivo. Prepared liposomal amphotericin B by both methods has particle size smaller than 150 nm, quite homogeneous and the entrapment drug was greater than 90%. The antifungal activity of liposomal amphotericin B was studied on three strains Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus fungal infection in mice models. Our results have shown that liposomal amphotericin B prepared by both methods have strong effect to prolong the survival in the infected mice and significantly reduced the Colony Forming Units (CFU) in target organ with similar effect of AmBisome.
  Hai Nguyen Thanh , Hue Pham Thi Minh , Loi Vu Duc and Tung Bui Thanh
  We investigate the effects of Coenzyme Q10 (CoQ10) supplementation on methamphetamine (METH)-induced neurotoxicity in the mouse brain. We used 30 mice divided into three groups containing 10 animals each: a control group, a brain injury group treated with METH and a group treated with METH+CoQ10. Various assays, such as protein thiol group, glutathione total, lipid peroxidation, catalase, superoxide dismutase and glutathione peroxidase, were used to assess the damage caused by METH and the protective effects of CoQ10 on brain tissues. The METH-induced brain injury significantly increased lipid peroxidation and decreased the level of the thiol group, the glutathione total and the activity of brain antioxidant enzymes (catalase, superoxide dismutase and glutathione peroxidase). The CoQ10 supplementation prevents all of these typically observed changes in METH-treated mice. Our results reveal that CoQ10 is potentially protective against METH-induced neurotoxicity in mice.
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