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Articles by Habibur Rahman
Total Records ( 2 ) for Habibur Rahman
  D. Sivaraman , P. Muralidharan and Habibur Rahman
  Objective: The aim of the present study is to evaluate the anxiolytic effect of a methanol extract of Ficus hispida Linn. Leaves in young adult mice. Materials and Methods: Anxiety in rodents was induced by administration of corticosterone (5 mg/kg/day), treated for 4 weeks developed an anxiety. Actophotometer, elevated plus maze, zero maze, hole board and rotarod paradigm were used to assess the anxiolytic activity of the methanolic leaf extract Ficus hispida Linn. (MEFH) at the dose of 200 and 400 mg kg-1. p.o. and diazepam 1 mg kg-1, i.p. were administered 30 min before the tests. Result: The results showed that the MEFH significantly increased the number of head poking and line crossing in the hole board test. In the elevated plus maze the MEFH at the dose of 400 mg kg-1 significantly increased the duration of exploration in open arm in similar way to that of diazepam. Further, in the zero maze the extract produced significant increase in time spent in open arm as compared to negative control. In the rotarod MEFH at the dose of 200 and 400 mg kg-1 significantly decreased the fall off time which shows the muscle relaxing property of the plant. The spontaneous locomotor activity count, measured using actophotometer, was significantly decreased in animal pretreated with MEFH. Indicating the remarkable sedative effect of the plant. Conclusion: The result of the present study suggests that leaves of Ficus hispida Linn. may possess an anxiolytic effect.
  D. Sivaraman , S. Shantha Kumar , P. Muralidharan and Habibur Rahman
  Background: To investigate the effect of Methanol root extract of Hemidesmus indicus (MEHI) on cerebral infract by four vessel occlusion method. Method: A total of 36 Sprague-Dawley (SD) rats were studies. In the present study the animals were pretreated with MEHI for a period of 1week (200 and 400 mg kg-1) p.o. Cerebral ischemia was established by permanent occlusion of vertebral artery followed by 15 min occlusion of bilateral carotid arteries. After 24 h of reperfusion the animal behavior were evaluated for neuromuscular function, vestibulomotor function and complex neuromotor function. The treatment was continued for another week after surgery with root extract and the animals were sacrificed and the brain was removed and homogenized. The homogenized content was used for the estimation of anti-oxidant enzymes and various neurotransmitter levels. Results: The group treated with 200 and 400 mg kg-1 MEHI showed significant (p<0.01) improvement in neuromuscular, vestibulomotor, complex neuromuscular function when compared with negative control group. Significant increase in brain anti oxidant enzymes was observed in MEHI treated group when compared to negative control. The MEHI treated groups exhibited a significant decrease in the levels of acetyl choline esterase, glutamate and monoamine oxidase-B. Increased levels of dopamine and serotonin were observed in the treated group when compared with ischemic group. Conclusion: MEHI can improve the neurological status and may reduce the cerebral infract in ischemia-reperfusion injured rats.
 
 
 
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