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Articles by H.Y. Wakawa
Total Records ( 2 ) for H.Y. Wakawa
  H.Y. Wakawa and M. Hauwa
  The aqueous leaf extract of Erythrina senegalensis (ES) was evaluated for its protective activity against carbon tetrachloride (CCl4)-induced liver injury. A 100, 200 and 400 mg kg-1 b.wt. of the ES leaf extract was administered to different groups of rats for 7 days prior to the CCl4 administration. A significant (p<0.05) decrease was observed in both the groups pretreated with 200 and 400 mg kg-1 b.wt. of the leaf extract on the levels of the enzymes and non enzyme markers of tissue damage, lipid peroxidation and relative organ weights and this is shown to be dose dependant when compared to rats that were given CCl4 only. These results showed that ES possess hepatoprotective principle (s) that was (were) able to prevent the toxicity of CCl4 against the liver of rats.
  D. Dahiru , D.N. Mamman and H.Y. Wakawa
  The aqueous extract of Ziziphus mauritiana fruit (Zm) was evaluated for its protective activity against CCl4-induced liver damage. 250, 500 mg/kg bw of Zm fruit extract or 100 mg/kg silymarin (standard) were administered to different groups of rats prior to CCl4 administration. Both 250 and 500 mg/kg bw of Zm fruit extract significantly (p<0.05) reduced (dose dependently) the levels of enzymes and non-enzymes markers of tissue damage when compared to rats given CCl4 only. These findings were supported by liver histology and suggest that Zm fruit possessed reach hepatoprotective principles that inhibited the toxicity of CCl4 against the liver.
 
 
 
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