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Articles by H.M. Mousa
Total Records ( 3 ) for H.M. Mousa
  A.I. Al-Humaid , H.M. Mousa , R.A. El-Mergawi and A.M. Abdel-Salam
  Dates and camel milk have been reported to be used for prevention and treatment of various diseases in Arab countries. This study was designed to investigate the antioxidant activity of dates and camel milk, alone or as a mixture and their effect in lead acetate-poisoned rats. Lead was administered to rats in drinking water at a concentration of 0.6% to generate lipid peroxidation. Three cultivars of date fruits grown locally (Nabtat Ali, Sukkari and Rashudia) were tried when mixed individually with camel milk against lipid peroxidation generated by lead. Chemical composition of dates, camel milk and their mixture was determined. The organoleptic evaluation of palatability of date-camel milk mixtures was performed. Serum glucose, triglycerides and urea concentrations and activities of Aspartate Aminotransferase (AST/GOT), Alanine Aminotransferase (ALT/GPT) and Glutathione-S-Transferase (GST) enzymes were determined. Drinking water containing 0.6% lead acetate resulted in significant increase in serum glucose, triglycerides and urea concentrations, as well as increased activity of serum enzymes were investigated. It also reduced the serum activity of the antioxidant enzyme Glutathione-S-transferase. Mixing camel milk with date varieties of Rashudia, Nabtat Ali or Sukkari in ratio of 2:1 (v/w) increased milk antioxidant capacity by 49.2, 62.8 and 81.3%, respectively. It also reduced the elevated activities of serum enzymes, the concentration of urea and increased the activity of Glutathione-S-Transferase enzyme in poisoned rats. Mixtures of camel milk with the different cultivars of dates produced different beneficial effects. In conclusion, feeding a mixture of camel milk with dates seems to enhance the body defense against free radicals generated by the lead acetate poisoning mainly due to the high contents of phenolics and flavonoids in the mixture.
  N.A. Al-Wabel , H.M. Mousa , O.H. Omer and A.M. Abdel-Salam
  The aim of the present study was to investigate the biological effects of aqueous herbal extracts mixed with stirred yoghurt filtrate against alloxan-induced oxidative stress and diabetes in rats. Aqueous extracts of six medicinal plants: fenugreek, greater burdock, goat`s rue, colocynth, chicory and lupine were mixed with stirred yoghurt filtrate and used in the experiments. Blood glucose and alanine and aspartate aminotransferase (ALT and AST) activities were estimated before and after alloxan-induced oxidative stress and diabetes in rats. Obtained results showed that blood glucose levels in sera of treated rats fed on aqueous extract of medicinal plants and stirred yoghurt filtrate mixture decreased with mean values of 135.0 ± 26.85 mg/100 mL serum compared with the treated rat fed on basal diet (positive control) with mean value of 237.66 ± 14.43 mg/100 mL serum. Data showed that ALT and AST activities in sera of treated rat fed on aqueous extract of medicinal plants and stirred yoghurt filtrate mixture were nearest to the level of un-treated rats fed basal diet (negative control). The means values of ALT and AST level in treated group fed on aqueous extract of medicinal plants and stirred yoghurt filtrate mixture were 57.33 ± 20 and 189.33 ± 48.85 compared with the positive control 90 ± 31.76 and 260.00 ± 57.27 and negative control 44.66 ± 9.5 and 180.66 ± 23.58 U L-1, respectively. Data concluded that mixture of medicinal plant extracts and stirred yoghurt filtrate may play a role in protection against alloxan-induced oxidative stress and diabetes in rat.
  Khaled B. Alharbi , H.M. Mousa , Z.H. Ibrahim and I.M. El-Ashmawy
  Background and Objective: Environmental pollutants and toxic chemicals are widely spread and can cause hepatotoxicity. In developing countries plant extracts are the main source for treatment of many ailments. The objective of this study is to investigate the protective effect of methanolic extracts of Prosopis farcta and Lycium shawii against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Material and Methods: The two plants were collected, identified and extracts were prepared. Phytochemical analysis for total phenolics, total tannins content, non-tannins phenolics and total flavonoids was performed. Liver damage was induced in rats by repeated administration of CCl4 (30% in olive oil (3 mL kg–1 b.wt., i.p.). Liver protection was accomplished in 2 groups of rats by daily oral administration of extract of Prosopis farcta and Lycium shawii (250 mg kg–1 b.wt.,) for 15 days prior to CCl4 administration. Liver marker enzymes, serum total bilirubin, malondialdehyde (MDA), reduced glutathione (GSH), glutathione-S-transferase (GST), lipid profile, total antioxidant capacity were determined together with histopathological damage evaluation. Results: The CCl4 treatment increased significantly (p<0.05) liver marker enzymes, total bilirubin, MDA, GST, lipid profile and decreased significantly total serum protein, total antioxidant capacity, high density lipoprotein cholesterol (HDL-C) and GSH. Prosopis farcta and Lycium shawii treatment significantly reversed the CCl4-induced changes, towards normalcy. Conclusion: Liver protection capability of these two plants may be due to their high contents of various flavonoids that act as powerful antioxidants and free radical scavengers.
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