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Articles by H.I. Al-Sadi
Total Records ( 3 ) for H.I. Al-Sadi
  F.M. Al-Azawy and H.I. Al-Sadi
  The aim of this study was to investigate the protective activity of the synbiotics Biomin®Imbo and yoghurt against septic peritonitis in rats. Cecal Ligation and Tip Resection (CLTR) model was followed to induce fecal peritonitis. Effects of the synbiotics on survival after CLTR, acute phase proteins, pathological lesions, the Total and Differential Leukocytic Count (TLC and DLC) of the peritoneal fluid, the TLC and DLC of the peripheral blood and mean bacterial growth in the peritoneal cavity were studied. It was found that neither Biomin®Imbo nor yoghurt in the dose schedule used in this study prevented lethality at the end of the first and third day post induction (p.i.) of CLTR. No significant change was found in the values of the serum c-reactive protein in the various groups. Fibrinogen was elevated significantly in the groups in which septic peritonitis was induced. Gross and microscopic lesions that were observed in groups subjected to CLTR were comparable with those of bacteremia. There were generalized sepsis and fibrinous adhesions that were converted to fibrous adhesions after the 7th p.i. day. No significant change was noted in the cytologyof the peritoneal fluid in the various groups at the end of the first p.i. day. However, the TLC of the peripheral blood was significantly higher in rats of the experimental groups (with septic peritonitis) than in the control group. Yoghurt and to alesser extent Biomin®Imbo were found to lower insignificantly the bacterial growth in the peritoneal cavity at the end of the first p.i. day.
  A.M. Al-Aalim , H.I. Al-Sadi and N.S. Mechael
  The purpose of this study was to evaluate the oro-nasal route of immunization of rabbits against Pseudomonas aeruginosa keratitis. A local strain of P. aeruginosa that was previously isolated from human infected wounds was used in both preparation of vaccine, immunization and experimental animal infection. Animal infection was assessed using conventional clinical, bacteriological and pathological techniques. Immunized animals showed rapid bacterial clearance in comparison with non-immunized rabbits. Nonimmunized rabbits challenged with P. aeruginosa developed hyperemia of the conjunctiva, edema and suppurative inflammation at 24 h postchallenge. A single peripheral ring infiltrate covered 50-75% of the corneal diameter and 75% of stroma was involved with moderate to severe density. A moderate to severe anterior chamber reaction was seen. These changes increased in severity up to 96 h postchallenge and at this stage almost complete opacity was observed. In comparison, immunized rabbits showed complete or incomplete ring infiltrates at the periphery with moderate densities. Mild to moderate anterior chamber response and some hypopyon were also seen. At 96 h postchallenge, a 50% opacity was seen. These results were substantiated histopathologically. It was concluded that oro-nasal immunization provided moderate protection against P. aeruginosa keratitis in rabbits.
  K.M. Al-Saad , H.I. Al-Sadi and M.O. Abdul-Majeed
  The clinical, hematological, biochemical and pathological changes in naturally occurring zinc deficiency in sheep were described. Loss of appetite, alopecia, abnormal skin and decreased body weight constituted the main signs and symptoms. The respiratory and heart rates were significantly higher (p<0.05) in zinc deficient sheep than in normal control sheep. Values of total erythrocyte count, hemoglobin concentration and packed cell volume were significantly lower (p<0.05) in zinc deficient sheep than in normal control sheep. Significant differences were not found in the mean corpuscular volume, mean corpuscular hemoglobin concentration, total leukocyte count and differential leukocyte count values in sick and normal control sheep. The platelet count was significantly lower (p<0.05) in zinc deficient sheep than in normal control sheep. Values of other clotting indices (platelet volume, platelet distribution width, clotting time, prothrombin time and activated partial thrombo-plastin time) were significantly higher (p<0.05) in zinc deficient than in normal control sheep. Zinc, total protein, calcium, alkaline phosphatase and fibrinogen values in the serum were significantly lower (p<0.05) in zinc deficient than in normal control sheep. The levels of aspartate aminotransferase and alanine aminotransferase were significantly higher (p<0.05) in zinc deficient than in normal control sheep. Microscopic lesions of the skin of zinc deficient sheep were in the form of parakeratosis and in some cases hyperkeratosis.
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