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Articles by H.C.C. Maduka
Total Records ( 5 ) for H.C.C. Maduka
  H.C.C. Maduka , A. Salihu and V.A. Onwuliri
  Combination drug interaction between sodium phenobarbitone and halofantrine was studied biochemically in weaning rats. Groups were made according to their body weights. All the rats were sacrificed after 4 days of drug administration and the liver homogenates and blood prepared for biochemical and haematological investigations of cytotoxicity. Results showed that total protein contents, monooxygenase, acid phosphatase and alkaline phosphatase activities in the liver increased with increase in drug administered for all the tests compared with the drug free controls. In the haematological analysis, there was increase down the column with increase in drug for RBC, PCV and Hb while the reverse was the case for WBC (total and differential) compared with the controls. This would suggest that phenobarbitone had an overwhelming sparing effect on the depletion of the haematological parameters and induced their synthesis and lymphocytic maturation but inhibited eosinophil production. The result indicated that phenobarbitone affected the cytotoxic and haematological effects of halofantrine, an antimalarial drug.
  F.O. Obi , H.C.C. Maduka and Y.P. Mamza
  The effect of treatment with chloroquine and normal saline on blood glucose and serum cholesterol levels was investigated in alloxan-induced diabetic and non-diabetic rabbits. It was observed that high dose of chloroquine (25 mg kg‾1 body wt) administration twice daily for three consecutive days led to an increase in the blood glucose and decrease in the serum cholesterol levels. The possible mechanism for the hyperglycaemic and hypocholesterolemic effects being observed was x-rayed in the light of other reported observations of chloroquine administration.
  H.C.C. Maduka , Z.S.C. Okoye and M. Mahmood
  The amino acid profile and anionic composition of three aqueous preparations of Sacoglottis gabonensis stem bark were determined. Curde extract of Sacoglottis gabonensis stem bark prepared in 4% ethanol (1:10w/v), the deffated fraction of the ethanol crude extract and methanol extract (1:10w/v) were analyzed. The anionic composition analysis showed that in ethanolic extract, Cl- was present in highest amount followed by NO3- then F- and lastly SO42- being 27.7 ± 1.25, 6.82 ± 0.11, 5.10 ± 0.30 and 3.08 ± 0.11 ppm respectively. The deffated ethanol extract contained Cl- in highest quantity followed by SO42- and then NO3- and finally F-being 24.8 ± 0.98, 12.34 ± 0.15, 9.14 ± 0.38 and 5.10 ± 0.30 ppm respectively. The methanolic extract contained Cl-, SO42-, NO3- and F- to the extent of 30.3 ± 1.08, 6.77 ± 0.11, 4.77 ± 0.20 and 4.12 ± 0.18 ppm respectively of the anions. Results showed that while the ethanol crude extract contained eleven amino acids including seven essential amino acids (1 ys, Leu, Ile, Tyr, Thr, His and Val), the defatted extract and methanolic extract contained 13 and 17 amino acids respectively including all the nine essential amino acids. Both the defatted portion and methanolic extract contained Cys thus suggesting a role in detoxification of autooxidizable drugs. The bark extract can serve as alternative source of essential amino acids and hence relevant in nutrition. Toxic species like CN, Cd and Hg that could inhibit drug metabolizing enzymes were absent. Methanol is the best extractor while defatting unmasked Phe and Met which were not detected in the crude extract.
  F.O. Obi , H.C.C. Maduka and I. Zubairu
  The activities of L−alanine amino transferase and L−aspartate amino transferase in rabbit serum were assayed in the presence and absence of graded doses of congo red administered i.p. Blood was collected for a period of seven days from three groups of rabbits administered with 45 mg kg-1 body wt., 67.5 mg kg-1 body wt body and 90.0 mg kg 1 body wt., respectively and used for enzyme analysis. The result obtained showed that the two enzyme activities were inhibited significantly (P< 0.05) and the degree of inhibitions were dose-dependent with respect to the control group. Dose dependent inhibition of Congo red on the two transanminases was substantiated by varying percentage decreases of the enzyme activities as 37, 58.7 and 60.2% for the groups 1, 2 and 3, respectively for aspartate amino transferase. The same pattern of inhibition was observed for alanine amino transferase suggesting that both enzymes may be inhibited by similar mechanism.
  V.A. Onwuliri , S. Bitrus , F. Puppet and H.C.C. Maduka
  Serum lipid profiles (total cholesterol, phospholipids, total lipid) and electrolytes (Sodium ion, Na2+, potassium ion, K+ chloride ion, Cl- and bicarbonate ion, HCO3-) were determined in 100 diabetics attending the Diabetic Clinic of the Jos University Teaching Hospital and in non-diabetic subjects. All the diabetic patients had significantly higher (p<0.01) total cholesterol, phospholipids and total lipids levels than all the non-diabetic subjects. This study also showed a significant increase (p<0.05) in the serum levels of K+ and a non significant increase in the serum levels of HCO3- while there was a significant decrease (p<0.05) in the serum levels of Na+ and Cl- in all diabetics compared to all non-diabetics. There was however, a non-significant difference in the serum levels of these electrolytes between male diabetics and female diabetics. It is therefore concluded that differences in lipids and electrolytes found in diabetics may have a great potential as a diagnostic tool in clinical practice. The non-significant difference in the serum levels of both lipids and electrolytes between male and female suggests that sex plays no important role in the pattern of biochemical response to diabetes mellitus.
 
 
 
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