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Articles by H. Yuan
Total Records ( 2 ) for H. Yuan
  H. Yuan and C. Zhao
  3T3-L1 cell line is a model for studying adipose differentiation. Transcription factor 21 (Tcf21) positively regulates bone morphogenetic protein 4 (BMP4) expression, while BMP4 can up regulate differentiation of white adipocytes. So Tcf21 is a gene in the pathway of regulation of white adipocyte differentiation. In the present study, results of oil and red O staining showed that 3T3-L1 preadipocytes successfully differentiated into adipocytes by inducers. The RNA of mice white adipose tissues were harvested from the peri-uterine fat pads of female and the epidydimal fat pads of male KUNMING (KM) mice and RT-PCR results showed that Tcf21 expressed in primary white adipocytes and tissues of mice while its expression was not detectable in 3T3-L1 cell differentiation (from 3 to 192 h). So conclusion was draw that 3T3-L1 cell line can not reveal completely white adipogenesis in vivo and Tcf21 was absent in the pathway of regulation of 3T3-L1 adipose differentiation.
  P. J. Beisswenger , W. V. Brown , A. Ceriello , N. A. Le , R. B. Goldberg , J. P. Cooke , D. C. Robbins , S. Sarwat , H. Yuan , C. A. Jones and M. H. Tan
  Aim  To determine if a regimen with prandial + basal insulin compared with basal insulin attenuates post-meal inflammatory and glycative biomarkers in patients with Type 2 diabetes. Methods  This test-meal sub-study in the USA is from a previously reported clinical trial comparing the effect on glycaemic control of 24 weeks of thrice-daily pre-meal insulin lispro mix 50 (50% insulin lispro, 50% insulin lispro protamine suspension) or bedtime insulin glargine, both plus metformin. In the sub-study, glucose, insulin, triglycerides, high-sensitivity C-reactive protein, tumour necrosis factor α, interleukin-6, methylglyoxal and 3-deoxyglucosone were measured during the post-meal period of a mixed-meal breakfast at the final visit. Prandial + basal (n = 25) and basal (n = 21) insulin were administered at the same times as during the previous 24 weeks. Results  Post-meal, the prandial + basal insulin group had significantly higher insulin, lower glucose and triglycerides, as well as lower high-sensitivity C-reactive protein, tumour necrosis factor α and interleukin-6, than the basal insulin group. Glucose incremental area under the concentration curve significantly correlated with high-sensitivity C-reactive protein, tumour necrosis factor α, interleukin-6, methylglyoxal and 3-deoxyglucosone incremental area under the concentration curve. Insulin incremental area under the concentration curve correlated inversely with high-sensitivity C-reactive protein and tumour necrosis factor α incremental area under the concentration curve. However, after adjusting for glucose incremental area under the concentration curve, these inverse correlations were no longer significant. Triglyceride incremental area under the concentration curve was not correlated with any biomarker incremental area under the concentration curve. Conclusions  Controlling post-meal hyperglycaemia with prandial + basal insulin in patients with Type 2 diabetes attenuates meal-induced increases in high-sensitivity C-reactive protein, interleukin-6 and tumour necrosis factor α compared with basal insulin. The rise in post-meal glucose, but not triglycerides, significantly correlated with the rise in post-meal inflammatory and glycative biomarkers.
 
 
 
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