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Articles by H. Yu
Total Records ( 5 ) for H. Yu
  X. -Q. Yang , L. -J. Guo , C. -Y. Zhai , H. Yu , H. Liu and D. Liu
  This study was designed to clone the porcine calpain 7 gene, CAPN7, to characterize its tissue expression, and to investigate its genetic variation. The cDNA sequence that contains a 2442 bp open reading frame encoding 813 amino acids was obtained by reverse transcription-polymerase chain reaction and rapid amplification of cDNA ends methods based on in slico cloning and homologous cloning, and five introns were identified. Quantitative real-time PCR showed that CAPN7 was ubiquitously expressed in all tissues examined, and the mRNA level in muscles was low at 1-7-days-old and high from 90 to 270-days-old. In addition, two single nucleotide polymorphisms in coding sequence were identified and the polymerase chain reaction-restriction fragment length polymorphism methods were established to detect the polymorphisms. At each site, the distribution of three genotypes is significantly different (P<0.01) in Yorkshire, Duroc, Wild boar, and Min pigs.
  W.J. Liu , Y. Fang , G.X. Fang , M. Wang , H. Yu , X.L. Li , T.T. Feng , H. Chen and S. G. Yu
  In the present study, the keratins and Keratin-Associated Proteins (KAPs) are one of the largest gene families in mammalian genomes encode, which is a heterogeneous group of proteins that make up about 90% of the cashmere fiber. Also, it regarded as a candidate gene of cashmere production traits. In this study, we aimed to detect polymorphisms of KAP16.6 gene and to investigated their associations with cashmere production traits (fiber diameter, cashmere yield, down cashmere thickness, body weight after combed cashmere) of three local goat breeds in China. In Xinjiang goat, statistical evaluation revealed significant differences (p<0.05) between the fiber diameter and cashmere yield trait of GG genotype. In Nanjiang cashmere goat, it is no significant differences (p>0.05) between cashmere production traits. The missense mutation of KAP16.6 gene in 816 cashmere goat samples was firstly detected in three of Xinjiang local goat breeds. Also, parts of these samples were sequenced. The results showed that frequencies of the KAP16.6-G allele in Xinjiang goat (n = 220), Nanjiang cashmere goat (n = 310) and BoGeDa cashmere goat breeds (n = 286) were 0.705, 0.603 and 0.600, respectively. The χ2 test showed that the genotype distributions in these three cashmere goat breeds were in agreement with Hardy-Weinberg equilibrium. According to the classification of PIC, BoGeDa cashmere goat was more polymorphic at this locus. Then a missense mutation was described at KAP16.6 locus in Xinjiang local goat breeds for the first time. The results possibly revealed that the size polymorphism existed in the three Xinjiang local goat breeds.
  Xiuli Peng , B. Cao , G.Z. Deng , C.Y. Li , L.L. Ye and H. Yu
  The object of this study was to describe the echography characteristics of different abnormal ovaries and estimate their effect on dairy cow sterility. The ovaries of 74 infertile dairy cows were checked with transrectal real-time ultrasound (7.0 MHz) and echography characters of abnormal ovaries were described. Thereinto, ovarian abnormality occurred about 60% and the other 40% case hadn’t obvious echogenic change. Hypoplasia showed a little area within parenchyma anecho or poor echo which could discriminate it with any other ovarian abnormality. Even though appeared a little echo area, atrophic ovary had much little high echo dot. Although, quiescent ovary was also very little, it had some small follicles which couldn’t develop. Ultrasound image showed large liquid anecho area of large ovaries in cystic ovarian follicle and corpora lutea cases. Anecho area of cystic ovarian follicle had echo of cumulus oophorous and its wall smooth. Corpus luteum appeared much little poor echo dot in crude fluid-filled anecho area and some of them had anecho cavity. Ovaritis showed an enlarged echo area much hyper or strong echo spot distributed inside. The edge of ovary connected tightly with circumjacent tissues reflecting hyper-echo. Few little follicles appeared but no dominant follicle and luteum were scanned.
  J Kang and H. Yu

The spindle checkpoint is a cell cycle surveillance system that ensures the fidelity of chromosome segregation. In mitosis, it elicits the "wait anaphase" signal to inhibit the anaphase-promoting complex or cyclosome until all chromosomes achieve bipolar microtubule attachment and align at the metaphase plate. Because a single kinetochore unattached to microtubules activates the checkpoint, the wait anaphase signal is thought to be generated by this kinetochore and is then amplified and distributed throughout the cell to inhibit the anaphase-promoting complex/cyclosome. Several spindle checkpoint kinases participate in the generation and amplification of this signal. Recent studies have begun to reveal the activation mechanisms of these checkpoint kinases. Increasing evidence also indicates that the checkpoint kinases not only help to generate the wait anaphase signal but also actively correct kinetochore-microtubule attachment defects.

  L Wang , T Yi , M Kortylewski , D. M Pardoll , D Zeng and H. Yu

Although the Th17 subset and its signature cytokine, interleukin (IL)-17A (IL-17), are implicated in certain autoimmune diseases, their role in cancer remains to be further explored. IL-17 has been shown to be elevated in several types of cancer, but how it might contribute to tumor growth is still unclear. We show that growth of B16 melanoma and MB49 bladder carcinoma is reduced in IL-17–/– mice but drastically accelerated in IFN-–/– mice, contributed to by elevated intratumoral IL-17, indicating a role of IL-17 in promoting tumor growth. Adoptive transfer studies and analysis of the tumor microenvironment suggest that CD4+ T cells are the predominant source of IL-17. Enhancement of tumor growth by IL-17 involves direct effects on tumor cells and tumor-associated stromal cells, which bear IL-17 receptors. IL-17 induces IL-6 production, which in turn activates oncogenic signal transducer and activator of transcription (Stat) 3, up-regulating prosurvival and proangiogenic genes. The Th17 response can thus promote tumor growth, in part via an IL-6–Stat3 pathway.

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