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Articles by H. Yoshida
Total Records ( 4 ) for H. Yoshida
  M. Hiramatsu , M. Oguri , K. Kato , T. Yoshida , T. Fujimaki , H. Horibe , K. Yokoi , S. Watanabe , K. Satoh , Y. Aoyagi , M. Tanaka , H. Yoshida , S. Shinkai , Y. Nozawa , T. Murohara and Y. Yamada
  Aims  We previously showed that the C[RIGHTWARDS ARROW]T polymorphism (rs6929846) of BTN2A1 was significantly associated with myocardial infarction in Japanese individuals by a genome-wide association study. Given that diabetes mellitus is an important risk factor for myocardial infarction, the association of rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to diabetes. The purpose of this study was to examine the relation of rs6929846 of BTN2A1 to Type 2 diabetes mellitus.

Methods  A total of 8650 Japanese individuals from two independent subject panels were examined: Panel A comprised 1141 individuals with Type 2 diabetes and 3161 control subjects and panel B comprised 1664 individuals with Type 2 diabetes and 2684 control subjects.

Results  The chi-square test revealed that rs6929846 of BTN2A1 was significantly related to the prevalence of Type 2 diabetes in subject panel A (P = 0.0002) and subject panel B (P = 0.006). Multivariable logistic regression analysis with adjustment for age, sex, body mass index and smoking status revealed that rs6929846 was significantly associated with Type 2 diabetes (P = 0.0006; odds ratio 1.25) in all individuals, with the T allele representing a risk factor for this condition. Multiple regression analysis with adjustment for age, sex and body mass index revealed that rs6929846 was significantly (P = 0.04) related to blood glycosylated haemoglobin content in control subjects.

Conclusions BTN2A1 may be a susceptibility gene for Type 2 diabetes in Japanese individuals.

  H Kimura , X Li , K Torii , T Okada , K Kamiyama , D Mikami , N Takahashi and H. Yoshida
 

Background. Long-term treatment with glucocorticoids (GCs) reportedly exaggerates renal fibrosis in chronic progressive inflammatory kidney disease. GCs induce the gene expression of plasminogen activator inhibitor-1 (PAI-1), a fibrosis enhancer in non-renal cells. Tumour necrosis factor-alpha (TNF-) reduces the gene expression of 11β-hydroxysteroid dehydrogenase (HSD) 2, an inactivator of GCs, and may enhance GC activity. However, the individual and collective effects of adrenal steroids, TNF- and HSD2 status on PAI-1 production are unknown in human proximal renal tubular epithelial cells (HPTECs).

Methods. Confluent HPTECs were treated with adrenal steroids (10 nM to 10 µM) or TNF- (10 ng/ml) for up to 48 h. The mRNA amounts of the target genes were determined by TaqMan quantitative PCR, and the PAI-1 protein amounts were measured by an immunoassay.

Results. Dexamethasone (DXA) maximally increased the amounts of PAI-1 mRNA and protein at 100 nM. Aldosterone (Ald) increased PAI-1 expression dose dependently, but the effect was over 100-fold weaker than that of DXA. The PAI-1-increasing effects of DXA and Ald were abolished completely by U-486, a specific inhibitor of the glucocorticoid receptor (GR) but not by spironolactone, a specific inhibitor of the mineralocorticoid receptor. The effect of DXA was also blocked partially by AG1478 and herbimycin A, tyrosine kinase inhibitors. DXA further increased TNF--stimulated PAI-1 expression via the GR. Although TNF- treatment caused an 80% reduction in the gene expression of HSD2, an inactivator of GCs, HSD2 inhibition did not enhance DXA-induced PAI-1 production.

Conclusions. DXA induces basal and TNF--stimulated PAI-1 expression via the GR pathway, regardless of HSD2 status in HPTECs. Excess GCs may serve as a pro-fibrotic factor in chronic inflammatory kidney diseases.

  T. Mizuno , Y. Kanai , J. Kataoka , M. Kiss , K. Kurita , M. Pearce , H. Tajima , H. Takahashi , T. Tanaka , M. Ueno , Y. Umeki , H. Yoshida , M. Arimoto , M. Axelsson , C. Marini Bettolo , G. Bogaert , P. Chen , W. Craig , Y. Fukazawa , S. Gunji , T. Kamae , J. Katsuta , N. Kawai , S. Kishimoto , W. Klamra , S. Larsson , G. Madejski , J.S.T. Ng , F. Ryde , S. Rydstrom , T. Takahashi , T.S. Thurston and G. Varner
  The energy response of plastic scintillators (Eljen Technology EJ-204) to polarized soft gamma-ray photons below 100keV has been studied, primarily for the balloon-borne polarimeter, PoGOLite. The response calculation includes quenching effects due to low-energy recoil electrons and the position dependence of the light collection efficiency in a 20cm long scintillator rod. The broadening of the pulse-height spectrum, presumably caused by light transportation processes inside the scintillator, as well as the generation and multiplication of photoelectrons in the photomultiplier tube, were studied experimentally and have also been taken into account. A Monte Carlo simulation based on the Geant4 toolkit was used to model photon interactions in the scintillators. When using the polarized Compton/Rayleigh scattering processes previously corrected by the authors, scintillator spectra and angular distributions of scattered polarized photons could clearly be reproduced, in agreement with the results obtained at a synchrotron beam test conducted at the KEK Photon Factory. Our simulation successfully reproduces the modulation factor, defined as the ratio of the amplitude to the mean of the distribution of the azimuthal scattering angles, within ~5% (relative). Although primarily developed for the PoGOLite mission, the method presented here is also relevant for other missions aiming to measure polarization from astronomical objects using plastic scintillator scatterers.
  T. Saiki , S. Motokoshi , K. Imasaki , K. Fujioka , H. Yoshida , H. Fujita , M. Nakatsuka and C. Yamanaka
  Laser pulses generated in a laser oscillator were amplified by Nd/Cr:YAG ceramic amplifiers. The saturation of output-laser energy was experimentally observed. We found that the stimulated emission cross-section of Nd/Cr:YAG ceramics was effectively increased and the saturation fluence was effectively reduced to 0.1J/cm2 due to the energy transfer between excited Cr and Nd ions. The output-laser energy we calculated was compared with the experimental ones and the extractable stored energy in the Nd/Cr:YAG ceramics was evaluated. This laser material is suitable for high-repetition-rate operations because of the high laser gain with low pumping intensity and low effective saturation fluence.
 
 
 
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