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Articles by H. Nahrevanian
Total Records ( 2 ) for H. Nahrevanian
  E. Salehizadeh , H. Nahrevanian , M. Farahmand , R. Hajihosseini , R. Saghiri and G. Khalili
  Killed Leishmania Vaccine (KLV) has been applied for its immunogenicity in hosts. Imiquimod (IMQ) as adjuvant induces immune responses during leishmaniasis. In this study, KLV/IMQ were applied to inhibit the proliferation and visceralization of Leishmania major in mice. Animals were treated with KLV/IMQ, then they infected by promastigotes of L. major. Six weeks later, a small nodule was appeared leading to a large lesion and visceralisation. KLV/IMQ effects on physiopathology, lesion sizes, lesion delay, amastigote proliferation and leishmania detection in target organs were all studied. Data analysis of body weight, hepato/splenomegaly and survival rates indicated no significant differences among experimental groups. It is concluded that KLV/IMQ represented no cytotoxic effects but they partly had effects on lesion size and impressed number of amastigotes inside macrophages. Application of KLV/IMQ decreased visceralization in liver; induced NO in liver, spleen and plasma. Although, IMQ application solely decreased visceralization in lymph nodes but KLV/IMQ increased SGOT/SGPT, however they represented no effects in concentrations of plasma Cu/Zn. Unlike IMQ topical application, its injection presented no ameliorative affects on CL, however its inhibition systemic leishmaniasis is indicated here. IMQ efficacy may be associated with route, dose and number of injection, which require more investigations.
  P. Ghaffarinejad , M. Farahmand , H. Nahrevanian , M. Mohebali , F. Zaboli , Z. Zarei , B. Akhoundi , M. Barati and F.S. Ghasemi
  Leishmaniasis is a parasitic disease, caused by several Leishmania species. Clinical symptoms range from Cutaneous Lesions (CL) to severe Visceral Leishmaniasis (VL). The main cause of VL in Iran is Leishmania infantum and domestic dogs are the major reservoir host. Different methods are used for diagnosis of VL including the parasitology staining from tissue aspiration and determination of antibodies against VL. The aim of this study was to compare direct agglutination (DAT) and rKE16 dipstick rapid tests for VL in domestic dogs from Meshkin Shahr district, Ardabil Province, Northwestern Iran. Blood samples of 200 dogs from five different regions were collected and their sera tested with DAT and rKE16 methods. Collected data were compared for VL detection, antibody titers and their association with age, gender and location. The highest rate of infection was detected by DAT (24.5%) in compare to rKE16 (11.5%). Majority of dogs suffering from VL were 2-7 years old and more male infection (82%) was observed with the highest rate in Parikhan village. These findings showed that DAT has a higher sensitivity than rKE16 dipstick for dogs VL detection. More infection was observed among dogs from Parikhan village of Meshkin Shahr district, Ardabil province, Northwestern Iran.
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