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Articles by H. Li
Total Records ( 10 ) for H. Li
  J. D. Goldhaber-Fiebert , H. Li , S. Ratanawijitrasin , S. Vidyasagar , X. Y. Wang , S. Aljunid , N. Shah , Z. Wang , S. Hirunrassamee , K. L. Bairy , J. Wang , S. Saperi , A. M. Nur and K. Eggleston
  Aims The prevalence of Type 2 diabetes mellitus (DM) has grown rapidly, but little is known about the drivers of inpatient spending in low- and middle-income countries. This study aims to compare the clinical presentation and expenditure on hospital admission for inpatients with a primary diagnosis of Type 2 DM in India, China, Thailand and Malaysia.
Methods We analysed data on adult, Type 2 DM patients admitted between 2005 and 2008 to five tertiary hospitals in the four countries, reporting expenditures relative to income per capita in 2007.
Results Hospital admission spending for diabetic inpatients with no complications ranged from 11 to 75% of per-capita income. Spending for patients with complications ranged from 6% to over 300% more than spending for patients without complications treated at the same hospital. Glycated haemoglobin was significantly higher for the uninsured patients, compared with insured patients, in India (8.6 vs. 8.1%), Hangzhou, China (9.0 vs. 8.1%), and Shandong, China (10.9 vs. 9.9%). When the hospital admission expenditures of the insured and uninsured patients were statistically different in India and China, the uninsured always spent less than the insured patients.
Conclusions With the rising prevalence of DM, households and health systems in these countries will face greater economic burdens. The returns to investment in preventing diabetic complications appear substantial. Countries with large out-of-pocket financing burdens such as India and China are associated with the widest gaps in resource use between insured and uninsured patients. This probably reflects both overuse by the insured and underuse by the uninsured.
  R Wu and H. Li

Eukaryotic transcriptional regulation is mediated by the organization of nucleosomes in promoter regions. Most Saccharomyces cerevisiae promoters have a highly stereotyped chromatin organization, where nucleosome-free regions (NFR) are flanked by well-ordered nucleosomes. We have found that yeast promoters fall into two classes differing in NFR sharpness, and that this distinction follows a known transcriptional dichotomy in yeast genes. A class of yeast promoters having well-defined NFRs are characterized by positioned patterns of poly(dA:dT) tracts with several novel features. First, poly(dA:dT) tracts are localized in a strand-dependent manner, with poly(dA) tracts lying proximal to transcriptional start sites and poly(dT) tracts lying distal, and collectively define a symmetry axis that is coincident with NFR centers. Second, poly(dA:dT) tracts are preferentially "capped" by G:C residues on the terminus proximal to the symmetry axis. Both signature features co-vary with fine positional variations between NFRs, establishing a closely knit relationship between poly(dA:dT) tracts, their capping patterns, and the central coordinates of NFRs. We found that these features are unique to promoters with well-defined NFRs, and that these promoters display significant difference between in vitro and in vivo nucleosome occupancy patterns. These observations are consistent with a model in which localized and G:C-capped poly(dA:dT) tracts initiate or facilitate the formation of NFRs at their center, possibly with chromatin remodeling and transcriptional machines involved.

  A.M.J.B. Adikari , J. Xu , S. Casterlow , H. Li , E.R. Gilbert , A.P. McElroy , D.A. Emmerson , R.A. Dalloul , E.A. Wong and E.J. Smith
  Objective: The aim of this study was to screen the chLEAP-2 gene for DNA sequence variation and to evaluate the relationships among its haplotypes (based on haplogroups), expression levels, weight gain and lesion score in two chicken lines challenged with Eimeria maxima. Methodology: A total DNA sequence of 4.6 kb including the chLEAP-2 gene was screened by re-sequencing of individual amplicons. Sixteen SNPs, including seven each in the promoter and introns and two in exons, were identified. Results: One of the exonic single-nucleotide polymorphism (SNPs) was non-synonymous, involving a cysteine to tyrosine codon change. About 25% of the SNPs were in Hardy Weinberg equilibrium. Linkage disequilibrium (D’) among the SNPs ranged from 0.02-1.00. The haplotypes observed from the 16 SNPs were assembled into 5 haplogroups. The estimated frequencies of the haplogroups ranged from 0.17-0.23 in the combined chicken lines. Although not significant (p>0.05), the chLEAP-2 gene expression varied among haplogroups. Differences among haplogroups for lesion score and weight gain were consistent, but not statistically significant (p>0.05). However, Hap4 appeared to be the haplogroup least susceptible to coccidiosis. At a minimum, the data do not support an association between chLEAP-2 DNA sequence variation and symptoms of coccidiosis such as weight gain depression and lesion score. Conclusion: Therefore, earlier reports of differences between resistant and susceptible lines in chLEAP-2 expression may be due to trans-acting factors. The genomic results reported here provide resources for testing the trans-expression control theory and will be useful for future genotype:phenotype evaluation studies between chLEAP-2 and other traits in the chicken.
  Y Zhang and H. Li

To analyze the clinical and pathological characteristics of adrenal primitive neuroectodermal tumors for a better understanding of the disease.


A retrospective analysis of four cases of adrenal primitive neuroectodermal tumors (two male, two female; age 21–30, average 24) was made. All patients went through necessary endocrinological exams, computer tomography scans (for site-specific diagnoses) and pathological tests.


No positive result was reported in routine laboratory tests and endocrinological exams. Computer tomography scans showed bulk soft tissue masses with rough borders. The masses were 8–17 cm in diameter with solid–cystic changes. Among the four patients, one refused to receive treatment after definitiver diagnosis through needle biopsy, three received surgical treatments and their post-operative pathological exams all confirmed the diagnoses of primitive neuroectodermal tumors. During the follow-ups, the untreated patient died 6 months afterwards, one patient died 8 months after palliative treatment; one patient showed distant metastasis 13 months after surgery and did not respond well to both radio- and chemotherapy; one patient had local recurrence 1 month after surgery and is presently undergoing chemotherapy.


Adrenal primitive neuroectodermal tumor is a very rare tumor. It originates in primitive neuroectoderma and is found mainly in 20–30-year-old young populations. It has non-specific clinical or imaging manifestation and its diagnosis is mostly based on pathological examinations. The tumor is fast-developing, highly malignant with poor prognosis.

  L. Ai , S.H. Chen , Y.N. Zhang , X.N. Zhou , H. Li , M.X. Chen , J. Guo , Y.C. Cai , X.Q. Zhu and J.X. Chen
  The present study examined sequence variations in the Internal Transcribed Spacers (ITS) of nuclear ribosomal DNA (rDNA) and two mitochondrial DNA (mtDNA) regions, namely cytochromec oxidase subunit 1 (cox1), NADH dehydrogenase subunits 1 (nad1), among Metorchis orientalis metacercaria isolates from Guangxi in China. The sequences of ITS, pcox1 and pnad1 were amplified from 6 individual M. orientalis metacercariae and sequenced. The relevant sequences of other 7 trematode species belonging to 6 genera in 4 families were downloaded from GenBank and their phylogenetic relationships were re-constructed using the combined pcox1 and pnad1 mt DNA sequences with Trichinella spiralis as outgroup. The results showed that sequences of ITS rDNA, pcox1 and pnad1 of M. orientalis were 1131, 654 and 650 bp, respectively and they were quite conserved among the M. orientalis isolates. However, they were quite different from that of other species, phylogenetic analysis of the combined pcox1 and pnad1 mt DNA sequences were able to distinguish M. orientalis from different species of the Opisthorchiidae and trematodes in other families. Therefore, the ITS, cox1 and nad1 mt DNA sequences provide effective genetic markers for the specific identification of trematodes of the Opisthorchiidae family and have implications for studying their population biology, genetic structure, as well as molecular epidemiology.
  H. Li , S.H. Chen , Y.N. Zhang , L. Ai and J.X. Chen
  Fish tapeworm (Diphyllobothrium species) are endemic in many parts of the word, the commonest species being Diphyllobothrium latum. Human are the main definitive host of D. latum and the majority of individuals harbouring the parasite are asymptomatica. In this report, researchers describe a case of D. latum infection founded on routine detection of eggs in fecal. After the whole cestode gotten, PCR Molecular Method had been done for identification.
  L. Ai , M.X. Chen , S.H. Chen , Y.N. Zhang , H. Li , Y.C. Cai , Y. Lu , L.G. Tian , X.N. Zhou and J.X. Chen
  MicroRNAs (miRNAs) are small non-coding RNA which generate from large hairpin precursors and play important role on post-transcriptional regulators of target genes. Although, many individual miRNAs have recently been extensively studied, there has been very little research on miRNA transcriptomes in trematode. By the method of using high throughput Solexa sequencing technology, 11.02 million clean reads have been obtained of Paragonimus westermani. Among the clean reads, 1.14 million ones (10.37%) were perfectly mapped onto the S. japonicum genome which included 20,322 (0.69%) unique sequences. A number of 9,492,613 (86.17%) reads had no match with public databases and marked as un-annotated RNAs. Nucleotide bias analysis found that the known miRNAs showed high bias and the guanine was the dominant nucleotide, particularly at the 2nd and 23rd positions which were almost at the beginning and end of conserved miRNAs. Three novel miRNA corresponding to 18 precursors were predicted. To the knowledge, this is the first report of miRNA profiles in P. westermani which will contribute to better understanding of the complex biology of this zoonotic parasite. The reported data of P. westermani miRNAs should provide valuable references for miRNA studies of closed related zoonotic trematode.
  M Liao , X Chen , J Han , S Yang , T Peng and H. Li

Huntingtin-associated protein-1 (HAP1) was initially identified as a binding partner of huntingtin, the Huntington's disease protein. Based on its preferred distribution among neurons and endocrine cells, HAP1 has been suggested to play roles in vesicular transportation in neurons and hormonal secretion of endocrine cells. Given that HAP1 is selectively expressed in the islets of rat pancreas, in this study, we analyzed the expression pattern of HAP1 in the islets. In rats injected intraperitoneally with streptozotocin, which can selectively destroy β-cells of the pancreatic islets, the number of HAP1 immunoreactive cells was dramatically decreased and was accompanied by a parallel decrease in the number of insulin-immunoreactive cells. Immunofluorescent double staining of pancreas sections showed that, in rat islets, HAP1 is selectively expressed in the insulin-immunoreactive β-cells but not in the glucagon-immunoreactive -cells and somatostatin immunoreactive -cells. In isolated rat pancreatic islets, ~80% of cells expressed both HAP1 and insulin. Expression of HAP1 in the INS-1 rat insulinoma cell line was also demonstrated by immunofluorescent staining. Western blotting further revealed that HAP1 in both the isolated rat pancreatic islets and the INS-1 cells also has two isoforms, HAP1A and HAP1B, which are the same as those in the hypothalamus. These results demonstrated that HAP1 is selectively expressed in β-cells of rat pancreatic islets, suggesting the involvement of HAP1 in the regulation of cellular trafficking and secretion of insulin. (J Histochem Cytochem 58:255–263, 2010)

  H. Li and G. Yan
  To portably monitor the motility of the total GI tract, a method for assessing GI motility by simultaneously measuring transit time and contraction frequency is put forward. The portable monitoring system is composed of a swallowable telemetric capsule, a portable recorder, magnetizing coils deposited in vitro, and workstation for data processing. The transit time and contraction frequency of the GI tract are deduced by analysing the variation of the position and orientation angles of a telemetric capsule in time domain and frequency domain. AC electromagnetic localization method is used to determine the position and orientation of the telemetric capsule in vivo. In the paper, the localization model based on a quasi-static magnetic field, the method of monitoring GI motility and the set-up of the monitoring system are detailed. Then from static and dynamic experiments, the performances of the system including the accuracy and dynamic response are evaluated. Finally, the electromagnetic safety of the system is verified by simulating electromagnetic radiation to the human body.
  J. H. Wang , B. Y. Zhang , W. Z. Qu , H. S. Chu and H. Li
  It is known that the electro-optical behaviour of polymer-dispersed liquid crystals depends on the separation of the polymer and liquid crystal phases. The morphology of the liquid crystal domains depends on the nature of the chemical and physical processes occurring during domain formation. This work discusses the two-phase morphology found in an acrylate-based system that develops during polymerisation-induced phase separation. The effect of the dopant nano-graphite on the polymerisation and electro-optical properties are discussed. UV/VIS and time-resolved Fourier transform infrared spectroscopy is used for monitoring the polymerisation of the polymer-dispersed liquid crystals. The electro-optical properties of the polymer-dispersed liquid crystal films are measured using a polarimeter (PerkinElmer Model 341). The morphology of the liquid crystal droplets in the polymer matrix is probed by polarising optical microscopy and Fourier transform infrared spectroscopy images. The threshold voltage of the polymer-dispersed liquid crystals is dramatically decreased because of the increased conductivity of the polymer matrix on doping by nano-graphite.
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