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Articles by H. Hosoya
Total Records ( 1 ) for H. Hosoya
  M Morita , K Hamao , S Izumi , E Okumura , K Tanaka , T Kishimoto and H. Hosoya
 

The large GTPase dynamin is strongly accumulated in the constricted area including midzonal microtubules of dividing cells. The proline-rich domain (PRD) of dynamin has been considered as a microtubule-binding domain. However, it remains unclear how PRD controls dynamin–microtubule interaction in mitotic cells. Here, we found that the microtubule-binding activity of PRD is low in dynamin-2. One of the mitosis-specific kinase activities to PRD in HeLa cells was identified as cyclin B-Cdc2 kinase. The kinase phosphorylated PRD at Ser764 and/or Thr766 and reduced the microtubule-binding activity of PRD. These results suggest that phosphorylation of PRD by cyclin B-Cdc2 kinase plays an important role to control dynamin-2–microtubule interaction in mitotic HeLa cells.

 
 
 
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