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Articles by H. Guo
Total Records ( 3 ) for H. Guo
  D Ouyang , X He , L Xu , X Wang , Q Gao and H. Guo

The major histocompatibility complex class I allele Mamu-B*17 of rhesus macaques is an elite controller of simian immunodeficiency virus (SIV) infection whereas Mamu-B*01 has no inhibitory effect on SIV replication. The mechanism is still elusive. In this study, the so-called ‘missing G’ in the leading peptide sequence of Mamu-B*1703 allele was artificially inserted back through PCR amplification, and the new sequence was renamed as Mamu-B*1703(+G). The plasmids harboring Mamu-B*1703, Mamu-B*1703(+G) and Mamu-B*0101 cDNA sequence fused to EGFP gene were transfected into K562 and Cos-7 cells, respectively. Our data showed that these plasmids had similar transfection efficiencies and expression potentials in K562 cells, but the surface density of Mamu-B*1703 complexes, which was slightly influenced by the artificial change of the leading peptide length, was much higher than that of Mamu-B*0101 molecules. These results might partially account for the differential effects of Mamu-B*17 and Mamu-B*01 alleles on SIV replication in rhesus macaques.

  Y.W. Nie , X.B. Ding , X.F. Liu , X.G. Ge , J.Y. Li , F.F. Yang , T. Guo and H. Guo
  The Cardiomyopathy Associated protein 1 (CMYA1) is a actin binding protein which plays an important role in cardiac morphogenesis. In this study, researchers obtained the 6,272 bp mRNA sequence of the cattle CMYA1 gene, including the full coding region and encoding a protein of 1,820 amino acids. The sequence was deposited into the GenBank nucleotide database (HQ111436.1). The human (NM_194293) and mice (NM_011724) homologues have a 77.31 and 82.23% identity with the cattle CMYA1 gene, respectively. Tissue expression analysis showed that the cattle CMYA1 gene was expressed exclusively in striated muscle tissue. Moreover, one deletion variant lacking 382 bp from exon 2 was detected by RT-PCR. Two synonymous SNP rs110346467 and SNP rs110575295 in the exon 2 detected, as restriction fragment length polymorphism showed genotype frequencies among 120 crossbred cattle. Association analysis showed that a SNP rs110575295 was significantly associated with the intermuscular fat percentage between 12th and 13th ribs (p<0.05). This study will lay the groundwork for the further investigations on the detailed function of CMYA1 in cattle models.
  C.W. Xiao , Y.S. Wang , L. Shi and H. Guo
  Based on Least Square Support Vector Machine (LSSVM) algorithm, a Sound Quality Prediction (SQP) model of vehicle interior noise during acceleration is presented in this study. The objective psychoacoustic parameters and subjective annoyance results are used as the input and output of the model, respectively. With correlation analysis, some psychoacoustic parameters, such as loudness, sharpness, roughness, articulation index and tonality, are selected for the modeling. The estimated values of unknown samples with the LSSVM SQP model are highly correlated with the subjective annoyance values, which has a higher accuracy than that with Multiple Linear Regression (MLR) model. Results show that the proposed LSSVM SQP model has good generalization ability and can be applied to the sound quality prediction of vehicle interior noise during acceleration.
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