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Articles by H. Goto
Total Records ( 2 ) for H. Goto
  Y. Wakabayashi , Y. Usui , Y. Okunuki , M. Takeuchi , T. Kezuka , T. Iwasaki and H. Goto
  Aim  To determine the intravitreous concentration of monokine induced by interferon-γ (Mig) in patients with diabetic retinopathy (DR) and the relation between Mig and vascular endothelial growth factor (VEGF).

Research design and methods  Vitreous samples were obtained at the time of vitrectomy from 41 eyes of 38 DR patients (30 with active DR and 11 with inactive DR) and from 15 eyes of 15 non-diabetic patients who had macular disease (control subjects). Human Mig and VEGF were quantified using a FACS Caliber® flow cytometer.

Results  The vitreous concentration of Mig was increased significantly in patients with both active and inactive DR [148.0 (31.6–997.2; median range) and 82.3 (25.7–347.7) pg/ml, respectively] compared with control subjects [21.0 (5.2–74.3) pg/ml; P < 0.0001 and P < 0.001, respectively]. In DR patients, a significant (P < 0.01) correlation was observed between vitreous concentrations of Mig and VEGF.

Conclusion  Our results suggest that Mig may play an important role in the pathogenesis of DR and works in consort with VEGF in the progression of pathological angiogenesis in DR.

  J. Ruttanavut , K. Yamauchi , H. Goto and T. Erikawa
  To investigate effects of a mixture of bamboo charcoal powder and bamboo vinegar solution (SB) on growth performance and histological intestinal change, 48 mixed sex Aigamo ducks were fed the basal commercial diet supplemented with SB at 0, 0.1 and 1% ad libitum for 49 days. Although, feed intake, weight gain and feed efficiency were not significantly different, the growth performance tended to be improved with increasing dietary SB. In these birds, also the intestinal villus height, villus area, epithelial cell area and cell mitosis in all intestinal segments tended to be increased with increasing dietary SB and increased in 1% dietary group (p<0.05). Besides, protuberated cells were observed on the villus apical surface in SB groups. These histological intestinal alterations of the villi and epithelial cells suggest that the intestinal function would be hypertrophied by the dietary SB and that the dietary SB can use at 1% level for Aigamo duck diets.
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