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Articles by H. Cheng
Total Records ( 3 ) for H. Cheng
  X Wang , W Xie , Y Zhang , P Lin , L Han , P Han , Y Wang , Z Chen , G Ji , M Zheng , N Weisleder , R. P Xiao , H Takeshima , J Ma and H. Cheng

Rationale: Unrepaired cardiomyocyte membrane injury causes irreplaceable cell loss, leading to myocardial fibrosis and eventually heart failure. However, the cellular and molecular mechanisms of cardiac membrane repair are largely unknown. MG53, a newly identified striated muscle-specific protein, is involved in skeletal muscle membrane repair. But the role of MG53 in the heart has not been determined.

Objective: We sought to investigate whether MG53 mediates membrane repair in cardiomyocytes and, if so, the cellular and molecular mechanism underlying MG53-mediated membrane repair in cardiomyocytes. Moreover, we determined possible cardioprotective effect of MG53-mediated membrane repair.

Methods and Results: We demonstrated that MG53 is crucial to the emergency membrane repair response in cardiomyocytes and protects the heart from stress-induced loss of cardiomyocytes. Disruption of the sarcolemmal membrane by mechanical, electric, chemical, or metabolic insults caused rapid and robust translocation of MG53 toward the injury sites. Ablation of MG53 prevented sarcolemmal resealing after infrared laser–induced membrane damage in intact heart, and exacerbated mitochondrial dysfunction and loss of cardiomyocytes during ischemia/reperfusion injury. Unexpectedly, the MG53-mediated cardiac membrane repair was mediated by a cholesterol-dependent mechanism: depletion of membrane cholesterol abolished, and its recovery restored injury-induced membrane translocation of MG53. The redox status of MG53 did not affect initiation of MG53 translocation, whereas MG53 oxidation conferred stability to the membrane repair patch.

Conclusions: Thus, cholesterol-dependent MG53-mediated membrane repair is a vital, heretofore unappreciated cardioprotective mechanism against a multitude of insults and may bear important therapeutic implications.

  J.J. Yan and H. Cheng
  The initial market size plays an important part in customer’s utility when durable goods with network externality are consumed. Considering initial market size, this study analyzed competition strategies between oligopolistic firms by using of Hotelling model and two-stage game. Results show that initial market size affects competition strategies and makes strategies are different with general products’ strategies. It is forecasted that unequal initial market sizes will eventually lead to monopoly. Then, an empirical analysis is used to exemplify theory analysis.
  J.J. Yan , Y. Wang and H. Cheng
  The fusion and transmission of information in decision level are helpful for battle decisions. The existing research was focused on the underlying information fusion and lack of the behavior analysis between participants. So in this study, Bayesian game is introduced to situation assessment to analyze the commander’s subjective thinking process in the situation assessment. Based on the deep analysis of the content and function of situation assessment, a kind of high-level framework of situation assessment is put up and the equilibrium state is got. The validity of the method is verified by a simulation. This study has great significance in the developing the battlefield situation assessment theory.
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