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Articles by H. Ashraf
Total Records ( 3 ) for H. Ashraf
  A. Esteghamati , H. Ashraf , O. Khalilzadeh , A. Rshidi , K. Mohammad , F. Asgari and M. Abbasi
  Aims The prevalence of diabetes is increasing dramatically worldwide. Less is known about whether this trend is similar among obese and lean individuals. Methods We analysed the data sets of three cross-sectional national surveys in adults aged 25–64 years: the National Health Survey-1999 (n = 21 576), and the national Surveys of Risk Factors of Non-Communicable Diseases (SuRFNCD)-2005 (n = 70 981) and SuRFNCD-2007 (n = 4233). Diagnosed diabetes was ascertained, and height and weight were measured in all surveys. In SuRFNCD-2005 and SuRFNCD-2007, fasting plasma glucose was used to identify subjects with newly diagnosed diabetes (≥ 7 mmol/l) and impaired fasting glucose (5.6 -6.9 mmol/l) among individuals not reporting diabetes. Results The prevalence of diagnosed diabetes (after adjustment for age, sex and residential area) was 2.5, 4.0 and 4.6% in 1999, 2005 and 2007, respectively. The total prevalence of diabetes increased from 7.7% in 2005 to 8.7% in 2007, about half of which was attributed to newly diagnosed disease (in both surveys). The prevalence of diabetes increased in all categories of obesity, with the most evident trend being among subjects with body mass index < 25 kg/m2. Conclusions The prevalence of diabetes among Iranian adults has increased more than 1.8-fold in a period of only 8 years since 1999. This is the first report from Iran, and urgent measures need to be taken in order to prevent the progression and worsening of the problem and emergence of its undesired consequences.
  A. Esteghamati , H. Ashraf , M. Nakhjavani , B. Najafian , S. Hamidi and M. Abbasi
  Aims  To assess the association of insulin resistance with increased urinary albumin excretion (UAE) in a cohort of Iranian Type 2 diabetic patients.

Methods  Three hundred and sixty-one men and 472 women with Type 2 diabetes were enrolled from three different outpatient clinics (Tehran, Iran) during the period 2005-2008. Patients with obstructive uropathy, severe heart failure, liver disease, cancer, autoimmune disease and macroalbuminuria were not included. Microalbuminuria (MA; defined as UAE ≥ 30 mg/day) was found in 242 (29.1%) patients; 591 (70.9%) subjects had normoalbuminuria (UAE < 30 mg/day). Insulin resistance was assessed using homeostasis model assessment of insulin resistance (HOMA-IR).

Results  HOMA-IR index values were higher in subjects with MA than those with normoalbuminuria (P < 0.00001). Adjusted values (for age, sex and duration of diabetes) of UAE and HOMA-IR were 11.81 ± 7.51 (mg/day) and 3.30 ± 2.21 in normoalbuminuric and 75.36 ± 55.57 (mg/day) and 4.98 ± 3.22 in the MA group, respectively (P < 0.00001 for all). Multiple regression analysis showed that UAE was predicted by HOMA-IR, independently of age, duration of diagnosed diabetes, triglycerides, waist circumference, metabolic control, blood pressure and related treatments (P < 0.00001). When patients were categorized into quartiles of HOMA-IR, those of the fourth quartile (i.e. the most insulin resistant) were at a higher risk of increased UAE than other quartiles [odds ratio (OR) 3.7 (95% confidence intervals 2.7-6.2)].

Conclusions  In Iranian Type 2 diabetic patients, albuminuria was strongly associated with insulin resistance. HOMA-IR is an independent predictor of UAE.

  Ikram-ul-Haq , H. Ashraf , S. Omar and M.A. Qadeer
  The present study is concerned with the production of amyloglucosidase by Aspergillus niger GCUCM-36. Effect of addition of different carbon sources and nitrogen sources on the production of enzyme was investigated. The enzyme formation was maximum (1180 IU/g/min) in the presence of glucose (1.0%) and NH4Cl (1.5% nitrogen). The production of enzyme reached maximum, (1180 IU/g/min) at 48 hours after incubation.
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