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Articles by H. Ghofrani
Total Records ( 3 ) for H. Ghofrani
  M. Parsa , S.N. Najafi , N. Jonaidi Jafari , M. Mohraz , A. Ghavamzadeh , B. Bahar , M. Izadi , M.H. Radfar and H. Ghofrani
  The present study was designed to determine diagnostic value of IL-6 and TNF-α in patients with fever and neutropenia. This is a prospective study of 133 patients admitted to two university hospital in Tehran, Iran with fever and neutropenia. Patients were divided two groups as low risk and high-risk groups. Cytokines level compared with Mann-Whitney test in study groups of patients and ROC curves used to determine best cut-off points level for cytokines discriminating risk groups. Mean age of patients was 26.8±2.5 years and 7.5% of patients allocated in low risk group. The mean IL-6 and TNF-α serum level below 17 pg mL-1 was defined as best cut-off point determining low risk group patients with sensitivity and specificity of 70 and 67.5% respectively. However, we cannot define a statistically significant cut-off point for TNF-α to use as a diagnostic test. 13.5% of patients of our study have positive blood cultures (6% gram-negative, 6% gram- positive, 1.5% fungi), but no statistical difference had found in serum IL-6 and TNF-α levels in blood culture groups. Despite our findings about IL-6 diagnostic value in neutropenic patients with fever and its advantages in discriminating risk groups of patients it seem necessary to design a randomized controlled trial before use of this marker.
  N. Jonaidi Jafari , M.H. Radfar and H. Ghofrani
  There are eight destructive earthquakes and 74 natural disasters happen annually all over the world. Iran is one of the 10 calamitous countries in the world. Natural disaster change the echo system and inanimate environment which we are living in. these changes can cause new pathogen or increase the pathogenicity of the available pathogens. This is a descriptive study. We collect data of infectious diseases such as acute severe watery diarrhea, dysentery, acute respiratory infection, suspected to malaria, suspected to measles, suspected to meningitis, hemorrhagic fever, acute icter, acute flaccid paralysis, suspected to brucellosis, tuberculosis and bitten by animals which refer to the health care center after one week of the disaster. The most common cases infections were acute respiratory tract infections. During the study period, 6241 cases refer to clinic because of acute respiratory tract infection. Gastrointestinal infections were the second common cause of referring to clinic. During one month, 738 cases refer to clinic because of gastrointestinal infection. Staging by incidence of other infectious diseases were in the next grade. Cold weather, lack of appropriate housing, lack of heating system, over crowded population in camps were reasons which increase the incidence of respiratory tract infection. So we should provide hygienic water and food and also provide heating system as soon as possible. If any infectious diseases happened, we should mobilize the health care center not to postpone treatment of patients. In this research, we report the incidence of infectious diseases within one month after the Bam earthquake.
  N. Jonaidi Jafari , M.H. Radfar , H. Ghofrani and H. Masoumi asl
  During the summer of 2005, an outbreak of cholera struck Iran, infecting 1118 individuals and killing 11 patients. The epidemic started from the Southern regions and rapidly disseminated across the country. In spite of early confirmation of the epidemic and emergent actions by the Ministry of Health, the disease continued to spread during the first few weeks. Unlike most previous epidemics in Iran and other countries in the region, which were caused by Vibrio cholerae O1 biotype El Tor serotype Ogawa, the most common causative agent was identified to be the Inaba serotype. The likely source of the disease came from the neighboring countries; examination of drinking water, irrigation water and agricultural products showed that consumption of raw unclean vegetables was the most common route of transmission. The outbreak frightened millions of Iranian citizens and caused millions of dollars in economic damage. The question is how we can predict and prevent possible future cholera epidemics and what we should do when they occur.
 
 
 
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