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Articles by H. G. Yu
Total Records ( 2 ) for H. G. Yu
  Y. C Lin , J Huang , Q Zhang , J. M Hollander , J. C Frisbee , K. H Martin , C Nestor , R Goodman and H. G. Yu
 

Ca2+ entry is delicately controlled by inactivation of L-type calcium channel (LTCC) composed of the pore-forming subunit 1C and the auxiliary subunits β1 and 2. Calmodulin is the key protein that interacts with the COOH-terminal motifs of 1C, leading to the fine control of LTCC inactivation. In this study we show evidence that a hyperpolarization-activated cyclic nucleotide-gated channel, HCN2, can act as a nonchannel regulatory protein to narrow the L-type Ca2+ channel current-voltage curve. In the absence of LTCC auxiliary subunits, HCN2 can induce 1C inactivation. Without 2, HCN2-induced fast inactivation of 1C requires calmodulin. With 2, the 1C/HCN2/2 channel inactivation does not require calmodulin. In contrast, β1-subunit plays a relatively minor role in the interaction of 1C with HCN2. The NH2 terminus of HCN2 and the IQ motif of 1C subunit are required for 1C/HCN2 channel interaction. Ca2+ channel inactivation is significantly slowed in hippocampus neurons (HNs) overexpressing HCN2 mutant lacking NH2 terminus and accelerated in HNs overexpressing the wild-type HCN2 compared with HN controls. Collectively, these results revealed a potentially novel protection mechanism for achieving the LTCC inactivation via interaction with HCN2.

  H Jin , V Guacci and H. G. Yu
 

A meiosis-conditional pds5 allele in yeast provides a more detailed understanding of homologue pairing and synaptonemal complex formation.

 
 
 
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