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Articles by H Ueda
Total Records ( 2 ) for H Ueda
  M Toyofuku , T Kimura , T Morimoto , Y Hayashi , H Ueda , K Kawai , Y Nozaki , S Hiramatsu , A Miura , Y Yokoi , S Toyoshima , H Nakashima , K Haze , M Tanaka , S Take , S Saito , T Isshiki , K Mitsudo and on Behalf of the j Cypher Registry Investigators
 

Background— Long-term outcomes after stenting of an unprotected left main coronary artery (ULMCA) with drug-eluting stents have not been addressed adequately despite the growing popularity of this procedure.

Methods and Results— j-Cypher is a multicenter prospective registry of consecutive patients undergoing sirolimus-eluting stent implantation in Japan. Among 12 824 patients enrolled in the j-Cypher registry, the unadjusted mortality rate at 3 years was significantly higher in patients with ULMCA stenting (n=582) than in patients without ULMCA stenting (n=12 242; 14.6% versus 9.2%, respectively; P<0.0001); however, there was no significant difference between the 2 groups in the adjusted risk of death (hazard ratio 1.23, 95% confidence interval 0.95 to 1.60, P=0.12). Among 476 patients whose ULMCA lesions were treated exclusively with a sirolimus-eluting stent, patients with ostial/shaft lesions (n=96) compared with those with bifurcation lesions (n=380) had a significantly lower rate of target-lesion revascularization for the ULMCA lesions (3.6% versus 17.1%, P=0.005), with similar cardiac death rates at 3 years (9.8% versus 7.6%, P=0.41). Among patients with bifurcation lesions, patients with stenting of both the main and side branches (n=119) had significantly higher rates of cardiac death (12.2% versus 5.5%; P=0.02) and target-lesion revascularization (30.9% versus 11.1%; P<0.0001) than those with main-branch stenting alone (n=261).

Conclusions— The higher unadjusted mortality rate of patients undergoing ULMCA stenting with a sirolimus-eluting stent did not appear to be related to ULMCA treatment itself but rather to the patients’ high-risk profile. Although long-term outcomes in patients with ostial/shaft ULMCA lesions were favorable, outcomes in patients with bifurcation lesions treated with stenting of both the main and side branches appeared unacceptable.

  H Ueda , M Kuwatani and K. W. Suzuki
 

Tidal vertical migration (TVM) of the calanoid copepods Pseudodiaptomus inopinus and Sinocalanus sinensis was investigated three times in August 2003 and March and August 2004 in the Chikugo River estuary, Japan, from the viewpoints of life history and position within the estuary. On each cruise, vertical samples were collected four or five times a day from stations along the estuary by filtering water samples through a 37-µm mesh. Stage ratios did not vary extremely during copepodid stages in P. inopinus, whereas in S. sinensis the ratios abruptly decreased with the development of early copepodid stages. The highest densities occurred mostly within the oligohaline zones but did not coincide with the turbidity maxima. TVM that would increase population retention in the estuary was observed in both copepodids and nauplii of both species during the day, while the night vertical distribution of P. inopinus was the reverse of the retention-associated pattern, indicating that diel vertical migration prevailed at night. Sinocalanus sinensis exhibited adaptive position-dependent TVM especially in daytime, in which the scales of TVM were larger in the seaward populations. The interspecific differences in the stage ratios and TVM patterns may be explained by species-specific trade-offs between adaptive strategies for predator avoidance and retention in the estuary.

 
 
 
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