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Articles by H Tsujii
Total Records ( 2 ) for H Tsujii
  A Fukumura , H Tsujii , T Kamada , M Baba , H Tsuji , H Kato , S Kato , S Yamada , S Yasuda , T Yanagi , R Hara , N Yamamoto , J Mizoe , K Akahane , S Fukuda , Y Furusawa , Y Iwata , T Kanai , N Kanematsu , A Kitagawa , N Matsufuji , S Minohara , N Miyahara , H Mizuno , T Murakami , K Nishizawa , K Noda , E Takada and S. Yonai
 

The features of relativistic carbon-ion beams are attractive from the viewpoint of radiotherapy. They exhibit not only a superior physical dose distribution but also an increase in biological efficiency with depth, because energy loss of the beams increases as they penetrate the body. This paper reviews clinical aspects of carbon-beam radiotherapy using the experience at the National Institute of Radiological Sciences. The paper also outlines the dosimetry related to carbon-beam radiotherapy, including absolute dosimetry of the carbon beam, neutron measurements and radiation protection measurements.

  H Tsujii , Y Eguchi , A Chenchik , T Mizutani , K Yamada and Y. Tsujimoto
 

We report the construction and application of a mammalian genome-wide RNAi library. The oligodeoxynucleotides encoding ~200,000 shRNA sequences that targeted 47,400 human transcripts were inserted into a lentivirus vector pFIV-H1-puro, and a pool of pseudovirus particles with a complexity of ~200,000 were used to infect target cells. From the cells surviving apoptogenic Fas stimulation, four candidate shRNA sequences were obtained that provided resistance to Fas-induced cell death, including two shRNAs for caspase-8, an shRNA for Bid, and an shRNA for Fas. The reconstructed shRNAs with these sequences were shown to reduce expression of the respective gene products and increase survival after Fas stimulation. When similar selection was performed for tunicamycin-induced apoptosis, no shRNA strongly inhibiting tunicamycin-induced cell death was isolated, although a few reconstructed shRNAs led to a slight increase of survival. Thus, this genome-wide shRNA library proved useful for selection of genes that are involved in cell death, but some limitation was also revealed.

 
 
 
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