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Articles by H Sugimura
Total Records ( 2 ) for H Sugimura
  T Takai , S Kanaoka , K. i Yoshida , Y Hamaya , M Ikuma , N Miura , H Sugimura , M Kajimura and A. Hishida

We previously reported that fecal cyclooxygenase 2 (COX-2) mRNA assay, detecting COX-2 mRNA in feces, is useful for identifying subjects with colorectal cancer (CRC). To further improve the sensitivity, we evaluated the usefulness of the combination of COX-2 mRNA and matrix metalloproteinase 7 (MMP-7) mRNA assays as a marker of CRC. The study cohort included 62 patients with CRC and 29 control patients without colorectal neoplasia. RNA was isolated from routinely collected fecal samples. The expression levels of COX-2 and MMP-7 mRNAs were determined by nested reverse transcription-PCR. PCR conditions were optimized where the specificity of fecal COX-2 and MMP-7 mRNA assay result in 100%. The sensitivity of each fecal assay was 87% [95% confidence interval (95% CI), 76-94%] and 65% (95% CI, 51-76%) for CRC, respectively. The sensitivity of fecal RNA test (either marker being positive) was high for CRC (90%; 95% CI, 80-96%). The sensitivity of the fecal RNA test was also high (93%; 95% CI, 80-98%) in patients with stage I or II who are often cured by surgical resection. The fecal RNA test using COX-2 and MMP-7 mRNAs improved the sensitivity to detect CRC without decreasing the specificity. These results suggest that the fecal RNA test would be a promising approach for CRC screening, although larger clinical investigations are indicated. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1888–93)

  H Sugimura and G. Theriault

Background Work ability is the ability of a worker to perform his job. The authors hypothesized that supervisor support influences the work ability of workers working in an information technology company located in Tokyo.

Aims To assess whether or not support from supervisors influences work ability.

Methods Two surveys using the Brief Job Scale Questionnaire and the Work Ability Index (WAI) were conducted, one in October 2007 and the other in October 2008 on the same cohort. Two cross-sectional analyses and a 1-year longitudinal analysis were conducted using multiple regression analysis. In addition, the relationships between supervisor support and each dimension of WAI were analysed separately.

Results The number of participants was 1157 males. Significant relationships were observed between supervisor support and WAI scores in both survey periods after adjusting for age, job demand, job control, work group size, job rank and job type. The 2007 Supervisor support was a significant predictor of 2008 WAI that raised the possibility that supervisor support does influence WAI scores. From the analysis of each dimension of WAI, a strong relationship between supervisor support and WAI was observed for the sections of the WAI that assessed work capacity but not for the sections that assessed the personal health status of respondents.

Conclusions Supervisor support is an important predictor of work ability. Supervisor support is associated with the questions of the WAI that assess not only work demands but also person's resources of the work ability model.

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