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Articles by H Okamoto
Total Records ( 3 ) for H Okamoto
  H Stracke , H Okamoto and C. Pantev
 

We investigated attentional effects on human auditory signal-in-noise processing in a simultaneous masking paradigm using magnetoencephalography. Test signal was a monaural 1000-Hz tone; maskers were binaural band-eliminated noises (BENs) containing stopbands of different widths centered on 1000 Hz. Participants directed attention either to the left or the right ear. In an "irrelevant visual attention" condition subjects focused attention on a screen. Irrespective of attention focus location, the signal appeared randomly either in the left or right ear. During auditory focused attention (left- or right-ear attention), the signal thus randomly appeared either in the attended ("relevant auditory attention" condition) or the nonattended ear ("irrelevant auditory attention" condition). Results showed that N1m source strength was overall increased in the left relative to the right hemisphere, and for right-ear versus left-ear stimulation. Moreover, when attention was focused on the signal ear (relevant auditory attention condition) and the BEN stopbands were narrow, the right-hemispheric N1m source strength was increased, relative to irrelevant auditory attention. Such increments were neither observed in the left hemisphere nor for wide BENs. These novel results indicate 1) left-hemispheric dominance and robustness during auditory signal-in-noise processing, and 2) right-hemispheric assistance during attentive and demanding auditory signal-in-noise processing.

  K Naoki , H Kunikane , T Fujii , S Tsujimura , N Hida , H Okamoto and K. Watanabe
  Objective

Combined paclitaxel and carboplatin is a standard regimen for inoperable non-small cell lung cancer (NSCLC). Although an every-3-week schedule is common, weekly paclitaxel is clinically effective for various cancers. A Phase I clinical trial was conducted to determine maximum-tolerated doses (MTDs) for weekly combined paclitaxel and carboplatin, and to evaluate anti-tumor response, toxicity and pharmacokinetics of paclitaxel in patients with inoperable NSCLC.

Methods

Twenty patients with inoperable NSCLC received weekly carboplatin at area under the curve (AUC) = 2 mg/ml min and paclitaxel. Paclitaxel was escalated if MTD was not reached. Three patients each were entered at levels 1 and 2 (level 1, paclitaxel 50 mg/m2 and carboplatin AUC = 2 mg/ml min; level 2, 60/2), six at level 3 (70/2), five at level 4 (80/2) and three at level 5 (90/2).

Results

One patient had grade 4 (G4) neutropenia at level 2, one had G3 hepatic toxicity at level 3 and one had G3 cardiac toxicity at level 4. MTD was not reached for all dose levels. Response rate (RR) was 35% (7/20) and median survival was 11.1 months. Severe neutropenia (G3 and G4) was seen in seven patients associated with greater AUC, peak concentration (Cmax) and the duration of plasma concentration >50 ng/ml of paclitaxel.

Conclusions

Weekly combined paclitaxel (up to 90 mg/m2) and carboplatin (AUC = 2 mg/ml min) was well tolerated. A higher dose intensity of paclitaxel can be given, and RR and survival are not less than the every-3-week protocol. The weekly regimen is an alternative for untreated inoperable NSCLC patients.

  T Fujii , H Kunikane , H Okamoto , K Watanabe , H Kunitoh , K Mori , A Yokoyama , H Fukuda , T Tamura and N. Saijo
  Objective

It is important to find optimal regimens of cisplatin (CDDP)-based third-generation chemotherapy and radiotherapy for patients with unresectable Stage III non-small cell lung cancer (NSCLC).

Methods

This Phase II study was designed to determine the toxicity and efficacy of two courses of chemotherapy (CDDP 80 mg/m2 on day 1 and irinotecan 60 mg/m2 on days 1 and 8) followed by accelerated hyperfractionated thoracic radiotherapy (60 Gy/40 fractions in 4 weeks) combined with daily carboplatin (CBDCA) administration. CBDCA was administered at a target area under the plasma level–time curve of 0.4 x (24 h creatinine clearance + 25), according to Calvert's formula.

Results

Twenty-six patients were enrolled in the study. The patients' median age was 63 years (range 40–74 years) and included 22 males and 4 females. Seven patients were Stage IIIA and 19 were Stage IIIB. Twenty had a performance status (PS) of 1 versus six with a PS of 0. There was one treatment-related death due to sepsis and pneumonia associated with Grade 4 neutropenia and diarrhea during chemotherapy. Grade 3 or 4 neutropenia and diarrhea were observed in 14 and 5 patients, respectively. Toxicity of the radiotherapy was mild. There were 0 complete response and 13 partial responses, giving a response rate of 50.0%. Median survival time and 2-year survival were 16.4 months and 21.5%, respectively. This study was designed with Simon's two-stage design, and the response rate did not meet the criteria to proceed to the second stage and the study was terminated early.

Conclusions

This regimen might be inactive for patients with unresectable Stage III NSCLC.

 
 
 
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