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Articles by H Martin
Total Records ( 2 ) for H Martin
  S Robinson , H Syddall , K Jameson , S Batelaan , H Martin , E. M Dennison , C Cooper , A. A Sayer and The Hertfordshire Study Group

Background: dietary patterns analysis takes account of the combined effects of foods and may be a more meaningful way of assessing dietary exposure than considering individual nutrients. Little is known about the dietary patterns of older adults in the UK.

Objective: to describe the dietary patterns of a population of community-dwelling older men and women and to examine factors associated with compliance with these patterns.

Setting and Participants: 3,217 men and women aged 59–73 years who were participants in the Hertfordshire Cohort Study.

Methods: diet was assessed using an administered food frequency questionnaire; dietary patterns were identified using principal component analysis.

Results: two dietary patterns were identified. The first was characterised by high consumption of fruit, vegetables, oily fish and wholemeal cereals (‘prudent’ pattern); the second was characterised by high consumption of vegetables, processed and red meat, fish and puddings (‘traditional’ pattern). High ‘prudent’ diet scores were more common in women, in men and women in non-manual classes and in non-smokers (all P < 0.05), whilst high ‘traditional’ diet scores were more common in men, in men and women who had partners and were associated with higher alcohol consumption (all P < 0.05).

Conclusions: we have described large variations in food consumption and nutrient intake amongst older adults that are likely to have implications for future health. The specific socio-demographic correlates of the dietary patterns provide insights into the contexts within which good and poor diets exist, and may help in the identification of opportunities for dietary intervention.

  U Fischer Rasokat , B Assmus , F. H Seeger , J Honold , D Leistner , S Fichtlscherer , V Schachinger , T Tonn , H Martin , S Dimmeler and A. M. Zeiher

Background— Intracoronary administration of bone marrow–derived progenitor cells (BMC) was shown to improve coronary microvascular function in ischemic heart disease. Because coronary microvascular dysfunction is implicated in the pathogenesis and prognosis of nonischemic dilated cardiomyopathy (DCM), we investigated the effects of intracoronary BMC administration in patients with DCM.

Methods and Results— Intracoronary infusion of BMC was performed in 33 patients with DCM by using an over-the-wire balloon catheter. Left ventricular contractility at baseline and after 3 months was assessed by analysis of left ventricular angiograms. Coronary hemodynamics were determined by intracoronary Doppler wire measurements. After 3 months, regional wall motion of the target area (contractility from –1.08±0.39 to –0.97±0.47 SD/chord, P=0.029) and global left ventricular ejection fraction (from 30.2±10.9 to 33.4±11.5%, P<0.001) were improved. Increase of regional contractile function was directly related to the functionality of the infused cells as measured by their colony-forming capacity. Minimal vascular resistance index was significantly reduced in the BMC-treated vessel after 3 months (from 1.53±0.63 to 1.32±0.61 mm Hg · s/cm; P=0.002, n=24), whereas no changes were observed in the reference vessel (from 1.60±0.45 to 1.49±0.45 mm Hg · s/cm; P=0.133, n=13). Twelve months after BMC infusion, N-terminal prohormone brain natriuretic peptide (NT-proBNP) serum levels were decreased, suggesting a beneficial effect on left ventricular remodeling processes (from 1610±993 to 1473±1147 pg/mL; P=0.038 for logNT-proBNP, n=26).

Conclusions— Intracoronary administration of BMC seems to be associated with improvements in cardiac contractile and microvascular function in patients with DCM. Thus, randomized blinded studies are warranted to evaluate potential clinical benefits of intracoronary BMC administration in patients with DCM.

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