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Articles by Guvenc GUVENEN
Total Records ( 2 ) for Guvenc GUVENEN
  Omer EMECEN , Berrin BERCİK INAL , Fusun ERDENEN , Murat USTA , Hale ARAL and Guvenc GUVENEN
  Aim: Inflammatory and immune cells, such as eosinophils, macrophages, and neutrophils, generate more reactive oxygen species in patients with asthma than they do in healthy individuals, and oxygen radicals contribute to tissue injury in asthma. We aimed to measure total oxidant status (TOS) and antioxidant status (TAS) in order to assess oxidative and antioxidative capacity. Eosinophil cationic protein (ECP), total IgE, and eosinophils (%) were measured to evaluate the level of inflammation. Materials and methods: The study included 56 non-smoking asthma patients that were followed-up at the respiratory disease and allergy outpatient clinics, where they received ongoing treatment for 5 months (May 2008-October 2008). Patients with malignancy or chronic diseases, such as DM, chronic renal disease, and rheumatoid arthritis, were excluded. The patients with asthma were divided into 2 subgroups according to the level of asthma control: controlled and partially controlled. Results: Despite the absence of statistically significant differences in TAS and TOS in the asthma and control groups (P > 0.05), the levels of ECP, eosinophils, and total IgE were higher in the asthma patients (27.4-16 mg/dL, P = 0.008; 2.8%-1.7%, P = 0.03; 59-19.3 IU/L, P < 0.001, respectively); there were no statistically significant differences between the asthma subgroups. Conclusion: Therapy administered to the asthmatic patients prevented generation of excess oxidants, although eosinophilic inflammation persisted.
  Mustafa SAHIN , Berrin BERCIK INAL , Sahin OGREDEN , Ozgur YIGIT , Hale ARAL and Guvenc GUVENEN
  Aim: The following metabolic parameters were assessed in patients with obstructive sleep apnea syndrome (OSAS) diagnosed by polysomnography (PSG): leptin, IFG (impaired fasting glucose), thyroid functions, thyroid autoantibodies, lipid parameters, insulin levels, HOMA-IR index, CRP, obesity, and metabolic syndrome frequency.
Materials and methods:
Three patient groups were defined based on apnea-hypoapnea index (AHI) levels (Group I: n: 11 male (M)/19 female (F); Group II: n: 19 M/10 F; Group III: n: 21 M/10 F) and 2 control groups (obese (n = 18 M/12 F) and normal (n = 12 M/18 F)) were included with comparable BMI value and age.
The frequencies of metabolic syndrome were compared between patient groups, and no significant difference was found, despite an increased frequency of metabolic syndrome from mild OSAS to severe OSAS. The following significant differences were observed for insulin values: normal controls versus obese controls (P < 0.0001), normal controls versus Group I (P = 0.014), normal controls versus Group II (P = 0.001), normal controls versus Group III (P < 0.0001), and Group I versus Group III (P = 0.026).
An increased frequency of metabolic syndrome and insulin resistance was found in OSAS patients. OSAS patients with metabolic syndrome and insulin resistance are at an increased risk of diabetes mellitus and cardiovascular diseases.
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